Tosylmethyl isocyanide (TosMIC Compound)

Tosylmethyl isocyanide (TosMIC Compound)

CAS Number
36635-61-7
Molecular Formula
C9H9NO2S
Purity
98.8 %

About Tosylmethyl isocyanide (TosMIC Compound)

Tosylmethyl isocyanide, also known as TosMIC, is a reagent used extensively in organic chemistry for the introduction of nitrile groups into molecules. It is particularly important in heterocyclic synthesis and diastereoselective reactions. TosMIC is widely employed in reactions such as the Van Leusen reaction, which f...

Tosylmethyl isocyanide (TosMIC Compound) Specifications

CAS Number
36635-61-7
Molecular Formula
C9H9NO2S
IUPAC NameORBotanical Name
1-(isocyanomethylsulfonyl)-4-methylbenzene
Canonical SMILES
C1=CC=C(C=C1)S(=O)(=O)CNC
InChI Key
CFOAUYCPAUGDFF-UHFFFAOYSA-N
InChI
InChI=1S/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3
EINECS Number
253-140-1
MDL Number
MFCD00159816
UNSPSC Code
12181900
eClass
32039000
HSN No
2933.39.90
Apperance
Pale yellow powder
IR
Standard spectrum
Purity
98.8 %
P-Toluene sulphonic acid
Not detected
Assay by HPLC (On Anhydrous basis)
98.50%
Shelf life
2 years
Hazard Statements
H302: Harmful if swallowed. H319: Causes serious eye irritation. H317: May cause an allergic skin reaction.
Precautionary Statements
P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P280: Wear protective gloves/eye protection/face protection. P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Van Leusen Reaction

TosMIC reacts with ketones to form nitriles, allowing the introduction of a one-carbon unit into a molecular structure. It is particularly useful in organic synthesis.

Heterocyclic Synthesis

TosMIC is employed in the synthesis of heterocyclic compounds, such as pyrroles and imidazoles, which are often used as biologically active molecules in pharmaceuticals.

Diastereoselective Reactions

Used in diastereoselective reactions with sugar-derived aldehydes, TosMIC aids in the synthesis of diastereomerically pure products.

Condition

Store in a cool, dry, well-ventilated area, away from moisture and heat sources. Keep the container tightly closed when not in use.

Packaging Options

Available in various packaging sizes; contact Scimplify for specific packaging details.

Tosylmethyl isocyanide (TosMIC Compound) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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