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Halogenation

Enables precise halogenation with advanced reactors, tailored protocols, and sustainable processes.

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1220 KL
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What is Halogenation?

Halogenation is a chemical process that introduces halogens—fluorine, chlorine, bromine, or iodine—into organic molecules. This reaction is pivotal in creating highly functionalized compounds for pharmaceuticals, agrochemicals, and specialty applications.

Cyanation reaction mechanism

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GMP Certification Logo
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WHO GMP Certification Logo
US FDA Logo
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GMP Certification Logo
Kosher Certification Logo
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WHO GMP Certification Logo
US FDA Logo
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Applications of Halogenation in key industries

Pharmaceuticals

Enables the synthesis of APIs and intermediates, enhancing the stability and bioavailability of drugs.

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Pharmaceuticals

Agrochemicals

Used to create herbicides, fungicides, and insecticides with improved potency and efficiency

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Agrochemicals

Industrial Chemicals

Facilitates the production of flame retardants, solvents, and high-performance materials with thermal stability and resistance.

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Industrial Chemicals

Halogenation in the Synthesis of Fluticasone Propionate

Halogenation plays a crucial role in the synthesis of Fluticasone Propionate, a fluorinated corticosteroid used in treating asthma and allergic conditions. The incorporation of fluorine enhances its anti-inflammatory potency and metabolic stability.

Reaction

Starting Material: Corticosteroid precursor

Fluorinating Agents: Diethylaminosulfur trifluoride (DAST) or Sulfur tetrafluoride (SF₄)

Solvent: Anhydrous dichloromethane (CH₂Cl₂)

Corticosteroid Precursor+DAST or SF4Selective FluorinationFluticasone Propionate\text{Corticosteroid Precursor} + \text{DAST or SF}_4 \xrightarrow[]{\text{Selective Fluorination}} \text{Fluticasone Propionate}
Corticosteroid Precursor+DAST or SF4Selective FluorinationFluticasone Propionate\begin{gathered} \text{Corticosteroid Precursor} + \text{DAST or SF}_4 \\[0.5em] \xrightarrow[]{\text{Selective Fluorination}} \\[0.5em] \text{Fluticasone Propionate} \end{gathered}

Other Chemistry Capabilities

Cyanation

Cyanation

Cyanation is a chemical process that introduces a cyano group (-CN) in...

Hydrogenation

Hydrogenation

Hydrogenation is a chemical process in which hydrogen (H2) is added to...

Biocatalysis

Biocatalysis

Biocatalysis harnesses the power of enzymes or microorganisms to catal...

Fluorination

Fluorination

Fluorination is a chemical process used to introduce one or more fluor...

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Why Choose Scimplify for Halogenation?

Specialized knowledge in fluorination, chlorination, bromination, and iodination for diverse applications.

High-precision systems for safe and efficient halogenation processes.

Eco-friendly processes and byproduct management ensure minimal environmental impact.

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Resources

Webinar

July 4, 2024

Enhancing Innovation in Fragrance Value Chain

👥 Speaker: Vilas Sahasrabuddhey
👤 Host: Hersh Manek - Business Head, Flavors & Fragrances, Scimplify
👤 Co-Host: Nikita Ghode - Senior Manager, Market Intelligence, Scimplify

Webinar

May 23, 2023

Key Strategies for Protecting IPR in R&D Outsourcing

👥 Speaker: Dr. T Pavan Kumar
👤 Host: Mr Karthik Kumar - Business Head, Pharmaceuticals, Scimplify