Polysorbate 80

Polysorbate 80

CAS Number
9005-65-6
Molecular Formula
(C64H124O26)n-multiple grades
Purity
101.2
E-Number E-433Fatty Acid: Oleic AcidHLB Value: 15.0Nonionic SurfactantsUSP, EP, Food grades

About Polysorbate 80

Polysorbate 80, also known as Tween 80, is a nonionic surfactant and emulsifier widely used in industrial applications to blend oil and water-based ingredients. It acts as a useful solubilizer and emulsifier. Polysorbate 80 is commonly used in pharmaceuticals, cosmetics, and food products. As a leading Polysorbate 80 ...

Polysorbate 80 Specifications

CAS Number
9005-65-6
Molecular Formula
(C64H124O26)n-multiple grades
IUPAC NameORBotanical Name
Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs. (9CI, ACI)
InChI Key
RGPBUVUVZKQNHD-MDZDMXLPSA-N
EINECS Number
34-18-05-90
FEMA Number
2917
MDL Number
MFCD00152531
UNSPSC Code
12161700
HSN No
34024200
Appearance
Yellow to Amber Oily Liquid
Colour in Gardner
3.7
PH 5% solution
6.58
Moisture %
1.86
Saponification Value
47
Hydroxly Value
75
Assay/ Polysorbate 80 purity
101.2

Food & Beverage Industry

Polysorbate 80 is a key food-grade emulsifier that enhances consistency and extends the shelf life of processed foods. In the U.S. food sector, it is widely used in ice creams, whipped toppings, bakery mixes, sauces, and dressings, where it helps maintain a smooth texture and prevents ingredient separation.

Cosmetics and personal care

Polysorbate is used as a surfactant and emulsifier to blend oil and water components, enabling smooth, uniform lotions and creams. It enhances product stability and texture.

Pharmaceuticals

In U.S. pharmaceutical formulations, Polysorbate 80 is used as a solubiliser, stabiliser, and dispersing agent for injectable drugs, vaccines, and oral liquids. It improves ingredient dispersion and protects biologics from aggregation.

Industrial and chemical formulations

In industrial processes, Polysorbate 80 plays a role as a wetting agent, dispersant, and emulsifier in coatings, paints, lubricants, agricultural sprays, and other chemical blends aimed at U.S. manufacturing applications

Research and Biotechnology Applications

For laboratories and biotech firms in the U.S., Polysorbate 80 is used to solubilize APIs, stabilise proteins, and act as a surfactant in cell culture, reagent preparation, and diagnostic formulations.

Metabolism

Polysorbates undergo degradation by auto-oxidation, producing reactive peroxides, in addition to hydrolysis. Exposure to light of polysorbate 80 aqueous solution leads autoxidation of the alkyl polyoxyethylene chain leading to the production of hydroperoxide derivatives. The peroxides cause oxidative damage to the protein molecule that makes up the formulation. The residual peroxides and the rate of peroxide generation as a result of light exposure are found to vary for polysorbate 80 of different grades/from different sources.

Temperature

Store at room temperature (15–30°C or 59–86°F)

Packaging Options

25 kg drums, 200 kg barrels, customized packaging for pharma & food applications

Polysorbate 80 FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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