Enabling Friedel-Crafts reactions for pharmaceuticals, agrochemicals, and other industries with advanced chemical synthesis.
Friedel-Crafts Reaction is a fundamental class of reactions in organic chemistry used to introduce alkyl or acyl groups into an aromatic compound. Discovered by Charles Friedel and James Crafts in 1877, these reactions are widely used in the synthesis of aromatic hydrocarbons, ketones, and other derivatives for applications in the pharmaceutical, agrochemical, and polymer industries.
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Crucial for synthesizing key intermediates and APIs, including anti-inflammatory and antibacterial compounds.
Enables the production of herbicides, fungicides, and insecticides with enhanced stability and efficiency.
Essential for creating aroma compounds and flavoring agents used in perfumes, cosmetics, and food products.
Facilitates the production of key intermediates for lubricants, dyes, and catalysts.
The Friedel-Crafts acylation reaction is a key step in the industrial synthesis of Ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID). This reaction is employed in the Boots synthesis route, one of the most efficient commercial processes for producing Ibuprofen.
Aromatic Substrate: Isobutylbenzene
Acylating Agent: Acetyl chloride (CH₃COCl)
Catalyst: Aluminum chloride (AlCl₃) (acts as a Lewis acid)
Solvent: Dichloromethane (CH₂Cl₂) or other aprotic solvents
Cyanation is a chemical process that introduces a cyano group (-CN) in...
Hydrogenation is a chemical process in which hydrogen (H2) is added to...
Biocatalysis harnesses the power of enzymes or microorganisms to catal...
Fluorination is a chemical process used to introduce one or more fluor...
From preclinical testing to formulation and regulatory support, our CRO services are designed to streamline your path to market with precision and expertise.
Enabling seamless production processes to meet your specifications and timelines with our CMO services, catering to both small-scale and large-scale production needs.
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Advanced reactor systems equipped to handle high temperatures and pressure with precision.
48” candle filters ensure the purity of pharmaceutical products through efficient separation processes.
Sustainable practices with eco-friendly waste treatment and solvent recovery systems reduce environmental impact.
Brine chilling units and a backflow boiler to maintain precise reaction conditions.
👥 Speaker: Vilas Sahasrabuddhey
👤 Host: Hersh Manek - Business Head, Flavors & Fragrances, Scimplify
👤 Co-Host: Nikita Ghode - Senior Manager, Market Intelligence, Scimplify
👥 Speaker: Dr. T Pavan Kumar
👤 Host: Mr Karthik Kumar - Business Head, Pharmaceuticals, Scimplify
