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Biocatalysis

Enabling the production of high-value chemicals like pharmaceuticals, agrochemicals, and more with precise and efficient synthesis of complex molecules.

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No of Manufacturers
644 KL
Capacity
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Reaction temp
Intersect

What is Biocatalysis?

Biocatalysis harnesses the power of enzymes or microorganisms to catalyze chemical reactions, enabling the efficient and sustainable synthesis of complex molecules. This green chemistry approach is crucial for producing high-value compounds in pharmaceuticals, agrochemicals, and specialty materials.

Cyanation reaction mechanism

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PMDA (Pharmaceuticals and Medical Devices Agency) Logo
FSSAI Certification Logo
GMP Certification Logo
Kosher Certification Logo
FDA Approved Certification Logo
EU GMP Certification Logo
GFSI Certification Logo
WHO GMP Certification Logo
US FDA Logo
PMDA (Pharmaceuticals and Medical Devices Agency) Logo
FSSAI Certification Logo
GMP Certification Logo
Kosher Certification Logo
FDA Approved Certification Logo
EU GMP Certification Logo
GFSI Certification Logo
WHO GMP Certification Logo
US FDA Logo
PMDA (Pharmaceuticals and Medical Devices Agency) Logo
FSSAI Certification Logo
GMP Certification Logo
Kosher Certification Logo
FDA Approved Certification Logo
EU GMP Certification Logo
GFSI Certification Logo
WHO GMP Certification Logo
US FDA Logo
PMDA (Pharmaceuticals and Medical Devices Agency) Logo
FSSAI Certification Logo
GMP Certification Logo
Kosher Certification Logo
FDA Approved Certification Logo
EU GMP Certification Logo
GFSI Certification Logo
WHO GMP Certification Logo
US FDA Logo
PMDA (Pharmaceuticals and Medical Devices Agency) Logo
FSSAI Certification Logo
GMP Certification Logo
Kosher Certification Logo
FDA Approved Certification Logo
EU GMP Certification Logo
GFSI Certification Logo
WHO GMP Certification Logo

Applications of Biocatalysis in key industries

Pharmaceuticals

Enables the synthesis of chiral drugs, antibiotics, and APIs with unmatched precision and efficiency.

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Pharmaceuticals

Agrochemicals

Used for producing bio-based pesticides, herbicides, and fertilizers with eco-friendly processes.

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Agrochemicals

Industrial Chemicals

Facilitates the creation of bio-based polymers, surfactants, and fine chemicals for diverse applications.

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Industrial Chemicals

Biocatalysis in the Synthesis of Sitagliptin

Sitagliptin, a DPP-4 inhibitor used in the treatment of type 2 diabetes, is synthesized using a highly efficient biocatalytic fermentation process. This approach utilizes enzymatic transformation to produce the key chiral intermediate, reducing the need for traditional chemical resolution methods.

Reaction

Substrate: A prochiral ketone intermediate

Enzyme: Transaminase (TA) - a biocatalyst that enables asymmetric amination

Cofactor Regeneration: Pyridoxal phosphate (PLP)

Prochiral Ketone Intermediate+Enzyme (Transaminase)+Amine DonorFermentation ProcessChiral Amine Intermediate\text{Prochiral Ketone Intermediate} + \text{Enzyme (Transaminase)} + \text{Amine Donor} \xrightarrow[]{\text{Fermentation Process}} \text{Chiral Amine Intermediate}
Prochiral Ketone Intermediate+Enzyme (Transaminase)+Amine DonorFermentation ProcessChiral Amine Intermediate\begin{gathered} \text{Prochiral Ketone Intermediate} + \text{Enzyme (Transaminase)} + \text{Amine Donor} \\[0.5em] \xrightarrow[]{\text{Fermentation Process}} \\[0.5em] \text{Chiral Amine Intermediate} \end{gathered}

Other Chemistry Capabilities

Cyanation

Cyanation

Cyanation is a chemical process that introduces a cyano group (-CN) in...

Hydrogenation

Hydrogenation

Hydrogenation is a chemical process in which hydrogen (H2) is added to...

Biocatalysis

Biocatalysis

Biocatalysis harnesses the power of enzymes or microorganisms to catal...

Fluorination

Fluorination

Fluorination is a chemical process used to introduce one or more fluor...

Our Services

CRO

CRO

From preclinical testing to formulation and regulatory support, our CRO services are designed to streamline your path to market with precision and expertise.

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CMO

Enabling seamless production processes to meet your specifications and timelines with our CMO services, catering to both small-scale and large-scale production needs.

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Why Choose Scimplify for Biocatalysis Reaction?

Optimal temperature and pH control for the most effective working of the used enzymes.

Stainless steel and glass-lined reactors prevent the deactivation of the enzymes.

Specialized bioreactors and strict environmental management to maximize yield and sustainability.

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Resources

Webinar

July 4, 2024

Enhancing Innovation in Fragrance Value Chain

👥 Speaker: Vilas Sahasrabuddhey
👤 Host: Hersh Manek - Business Head, Flavors & Fragrances, Scimplify
👤 Co-Host: Nikita Ghode - Senior Manager, Market Intelligence, Scimplify

Webinar

May 23, 2023

Key Strategies for Protecting IPR in R&D Outsourcing

👥 Speaker: Dr. T Pavan Kumar
👤 Host: Mr Karthik Kumar - Business Head, Pharmaceuticals, Scimplify