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Bempedoic Acid

Bempedoic Acid

CAS Number: 738606-46-7

Molecular Formula: C19H36O5

ATP‑Citrate Lyase InhibitorLDL‑C Management Oral ProdrugLipid‑Lowering AgentInhibits ACL & activates AMPKBCS Class IIIndia DCGI: Approved local MAHEU EMA: Authorized primary hypercholesterolemia

About Bempedoic Acid

Bempedoic Acid is an oral, once-daily ATP-citrate lyase inhibitor and prodrug activated by hepatic ACSVL1 enzyme. By interrupting early cholesterol biosynthesis, it lowers LDL-C and is indicated for patients intolerant to statins or requiring additional LDL-C reduction. Bempedoic Acid manufactured on the purpose of Car...

Synonyms

  • 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
  • bempedoic acid
  • ESP-55016
  • ESP55016
  • ETC-1002
View all

Bempedoic Acid Specifications

CAS Number
738606-46-7
Molecular Formula
C19H36O5
IUPAC Name
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
Canonical SMILES
CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
InChI Key
HYHMLYSLQUKXKP-UHFFFAOYSA-N
InChI
1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
PubChem CID
10472693
Melting Point
~87-92°C
Appearance
White to off-white crystalline powder
Protein Binding
~99.3%
Half‑Life
~21 ± 11 hours
Excretion
~70% urine, ~30% feces
GHS Classification
Low systemic toxicity; non-carcinogenic; avoid ingestion. Not classified as hazardous under standard lab handling.
Handling
Use standard lab PPE.
ICH Classification
Non-carcinogenic, non-mutagenic (per ICH S2(R1))

Cholesterol Synthesis Inhibition

Serves as a prodrug that inhibits ACL in hepatocytes, effectively reducing hepatic cholesterol and LDL-C levels.

API for Oral Lipid-Lowering Formulations

Used in the formulation of Nexletol® and fixed-dose combinations (e.g., with ezetimibe).

End use clarity

R&D and commercial production of lipid-lowering pharmaceuticals, particularly for patients unable to tolerate statins.

Prodrug Activation

Requires hepatic ACSVL1 enzyme-confers liver-specific activity, reducing muscle toxicity

Dual Action

Inhibits ACL and activates AMPK in vitro- may confer anti-inflammatory effects

Drug-Drug Interactions

Weak inhibition of OATPs and OATs; no CYP450 involvement minimizes interaction risk

BCS Class II

Low solubility, high permeability critical for formulation strategies

Storage

Store at 2–8 °C in a tightly sealed container; protect from moisture.

  1. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
  2. bempedoic acid
  3. ESP-55016
  4. ESP55016
  5. ETC-1002

Bempedoic Acid FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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