Tacrolimus

Tacrolimus

CAS Number
104987-11-3
Molecular Formula
C44H69NO12
Purity
99.97% Tacrolimus
Target I Host System: Actinomycetes / FungiCDMO Stage & Processing Capabilities: Microbial Fermentation → HPLC Chromatography → cGMP

About Tacrolimus

Tacrolimus (CAS No: 104987-11-3) continues to serve as a cornerstone calcineurin inhibitor within the global immunosuppressant market, where its high-potency macrolide structure is increasingly vital for preventing allograft rejection in renal, hepatic, and cardiac transplantation. The pharmaceutical landscape is witne...

Synonyms

  • tacrolimus
  • Fujimycin
  • 104987-11-3
  • Prograf
  • Tsukubaenolide
View all

Tacrolimus Specifications

CAS Number
104987-11-3
Molecular Formula
C44H69NO12
Molecular Weight
804.02 g/mol
Canonical SMILES
CC(C)CC1CC(C)CC(OC)C2OC(O)(C(CC2OC)C)C(=O)C(=O)N2CCCCC2C(=O)OC(C(C)C(O)CC=CC=C1)C(C)=CC1CCC(O)C(OC)C1
InChI Key
QJJXYPPXXYFBGM-LFZNUXCKSA-N
InChI
InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
EINECS Number
627-021-3
MDL Number
MFCD00869853
HSN No
29420090
Molecular Weight
804.02 g/mol
Purity
99.97% Tacrolimus
Physical appearance
White to off-white crystalline powder
Melting Point
127 °C
Boiling Point
871.7°C at 760 mmHg
Flash Point
481 °C
Density
1.19 g/cm3
pKa
9.97±0.70
Precise Quality
99.97%
PSA
178 Ų
logP
2.7
Precautionary Statement Codes
P201, P202, P260, P264, P270, P280, P301+P310, P308+P313, P314, P321, P330, P405, and P501
Hazard Classes and Categories
Acute Tox. 3 (Oral) Repr. 2

Pharmaceutical

A pharmaceutical primary standard to determine strength, quality, and purity in pharmaceutical analysis

Immunosuppressant

An immunosuppressive agent to prevent organ rejection in transplant patients

Calcineurin Inhibitor

A calcineurin inhibitor to study the inhibition of T-lymphocyte activation and cytokine production

Cell Culture Supplement

A cell culture supplement used as an in vitro T cell proliferation blocker in co-culture medium studies

Research Tool

A research tool to investigate neuroprotective and neuroregenerative properties in animal models

Topical Agent

A topical agent for the treatment of moderate-to-severe atopic dermatitis in patients who have failed other therapies

  1. tacrolimus
  2. Fujimycin
  3. 104987-11-3
  4. Prograf
  5. Tsukubaenolide

Tacrolimus FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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