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Thiophenol (Alternate CAS 33411-63-1), also known as Benzenethiol or Phenyl Mercaptan, is a foundational organosulfur building block and the simplest of the aromatic thiols. Characterised by its distinctively pungent, garlic-like odor and high nucleophilic reactivity, it serves as a versatile intermediate in the precision synthesis of pharmaceuticals, agrochemicals, and high-performance polymers. Sulfhydryl (-SH) group on the benzene ring allows for the efficient introduction of sulfur-containing moieties into complex molecular architectures through substitution, addition, and radical reactions. In the pharmaceutical industry, it is a critical precursor for various active ingredients, including antipsychotics and specialised preservatives like Thimerosal. Utility extends to the agrochemical sector for the production of potent insecticides and to materials science, where it is used to develop high-refractive-index monomers and sulfur-bridged photoinitiators. By ensuring high chemical purity and low moisture content, Thiophenol provides manufacturers with a reliable starting material for achieving high-yield, high-selectivity transformations in demanding chemical processes. We are a globally established Thiophenol manufacturer and various other elemental derivatives supplier, along with a broad portfolio of other speciality chemicals worldwide through comprehensive regulatory documentation (CoA), traceability, and consistent global supply capabilities, ensuring reliable lead times and quality assurance across all grades.
Thiophenol (Alternate CAS 33411-63-1), also known as Benzenethiol or Phenyl Mercaptan, is a foundational organosulfur building block and the simplest of the aromatic thiols. Characterised by its distinctively pungent, garlic-like odor and high nucleophilic reactivity, it serves as a versatile intermediate in the precision synthesis of pharmaceuticals, agrochemicals, and high-performance polymers. Sulfhydryl (-SH) group on the benzene ring allows for the efficient introduction of sulfur-containing moieties into complex molecular architectures through substitution, addition, and radical reactions. In the pharmaceutical industry, it is a critical precursor for various active ingredients, includ...
Chemical Properties & Specifications
S16-S26-S28-S36/37/39-S45
R10; R24/25; R26; R36/37/38
H226; H300 + H310 + H330; H315; H319; H335; H361; H371; H372; H410
P210; P280; P302 + P352 + P310; P304 + P340 + P310; P370 + P378
Full chemical-resistant suit, Viton or Nitrile gloves, safety goggles, and (SCBA) for large-scale spills
Key building block for the synthesis of phenothiazine derivatives and other CNS-active agents & Pharmaceutical Synthesis API sulfonamides
Intermediate for the production of Thimerosal, an organomercury compound widely used as a preservative in vaccines and ophthalmic products
Scaffold in the design of various sulfur-containing enzyme inhibitors and anti-inflammatory candidates
Vital precursor for the synthesis of organophosphorus insecticides and acaricides
Development of specialized sulfur-containing herbicides that require precise phenyl-thio linkages for biological efficacy
Synthesises sulfur-rich monomers for high-index optical lenses and coatings
Essential component in the manufacture of sulfur-bridged photoinitiators for UV-curable resins and 3D printing applications
Radical polymerization to control molecular weight and improve the thermal stability of specialized plastics
Store in a cool, dark, and well-ventilated area (15-25°C)
Keep away from ignition sources
(Extreme Malodor) Use specialized carbon scrubbers or bleach traps for exhaust vents to prevent environmental odor pollution
Reacts violently with strong oxidizing agents and strong bases. Incompatible with Copper, Brass, and other non-stainless metals
The sulfur atom in Thiophenol is more nucleophilic and less basic than the oxygen atom in Phenol. This allows it to react more efficiently with softer electrophiles and enables unique transformations that are not possible with oxygen-based analogs.
Glassware and spills can be neutralized using a solution of sodium hypochlorite (household bleach), which oxidizes the malodorous thiol to a non-volatile, odorless sulfonate.
Yes, in the presence of air (Oxygen) and a base or metal catalyst, Thiophenol easily oxidizes to form Diphenyl Disulfide. This is why it is often stored under a Nitrogen blanket.
Yes, high-purity grades are used in the electronics industry as a surface-modifying agent for gold and silver nanoparticles (Self-Assembled Monolayers/SAMs) due to the strong affinity of sulfur for noble metals.
