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Lansoprazole

Lansoprazole

CAS Number: 103577-45-3

Molecular Formula: C16H14F3N3O2S

Proton Pump Inhibitor (PPI)Pharmacopeia: USPChirality: Racemic mixtureTherapeutic: Antiulcer, anti-secretory

About Lansoprazole

Lansoprazoleis (CAS 103577-45-3), a potent, substituted Benzimidazole Proton Pump Inhibitor (PPI) API classified as an antiulcer and antisecretory agent. As a prodrug, Lansoprazole's therapeutic potency is unleashed within the highly acidic environment (pH < 4) of the gastric parietal cell canaliculi. There, Lansoprazo...

Synonyms

  • 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
  • AG 1749
  • AG-1749
  • AG1749
  • Agopton
View all

Lansoprazole Specifications

CAS Number
103577-45-3
Molecular Formula
C16H14F3N3O2S
Molecular Weight
369.361
IUPAC Name
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
Canonical SMILES
CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
InChI Key
MJIHNNLFOKEZEW-UHFFFAOYSA-N
InChI
1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
EINECS Number
2017-001-1
HSN No
2933.99.00
Assay by hplc (%w/w)
99.60%
Molecular Weight
369.361
PSA
87.080
LogP
4.38090
Melting point
178-182°C
Boiling point
555.8°C at 760 mmHg
Refractive index
1.591
Flash Point
289.9°C
pKa
2.34±0.37 (Occasionally)
Solubility
>55.4 [ug/mL] (The mean of the results at pH 7.4)
GHS Hazard Statements
H315 (96.3%): Causes skin irritation H319 (96.3%): Causes serious eye irritation H335 (95.6%): May cause respiratory irritation
Risk Statements
R36/37/38
Safety Statements
S26; S36
Precautionary Statement Codes
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Gastroenterology

(Gastric Acid Suppression) Short-term treatment and maintenance of Gastroesophageal Reflux Disease (GERD) and Erosive Esophagitis (EE)

Ulcer Management

(Ulcer Healing) Treatment of active Duodenal Ulcers, Gastric Ulcers, and those associated with NSAID use

Infectious Disease

(H. pylori Eradication) Key component in Triple Therapy regimens (Lansoprazole + two antibiotics) to treat H. pylori infections

Hypersecretory

(Acid Control Conditions) Management of pathological hypersecretory conditions, notably Zollinger-Ellison Syndrome (ZES)

Temperature Control

Refrigerated Storage Recommended: Store at 2°C - 8°C (36°F - 46°F). Heat accelerates chemical breakdown (hydrolysis and oxidation)

Atmospheric Stability

Protect from Light, Air, and Moisture. The APl is light and moisture-sensitive, leading to the formation of impurities (Sulfone and Sulfide derivatives). Store under a protective inert gas (e.g., Nitrogen or Argon)

Chemical Segregation

Store isolated from strong acids or acidic fumes to prevent pre-activation or degradation of the prodrug form

Shelf life control

Strict control and retesting of materials nearing expiration are required due to potential degradation products

Assay Caution

Lansoprazole API is chemically sensitive, requiring strict control over its exposure to heat, light, and humidity to prevent degradation and maintain assay purity

  1. 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
  2. AG 1749
  3. AG-1749
  4. AG1749
  5. Agopton

Lansoprazole FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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