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Gamolenic acid (GLA), or γ-linolenic acid or also known as ácido gamolénico (GLA borage oil manufacturer) is a biologically important omega-6 fatty acid. GLA bypasses (unlike many fatty acids) the delta-6-desaturase enzyme-frequently impaired due to aging, metabolic conditions, or chronic disease. GLA is efficiently converted into dihomo-gamma-linolenic acid (DGLA), a direct precursor to prostaglandin E1 (PGE1), a compound universally recognised for its anti-inflammatory and vasodilatory roles in the body. Endogenous production of GLA reduces in diabetes- (comprises cell membranes and impaired nerve signaling)-GLA supplementation provides essential structural lipids that help support nerve membrane integrity and normal nerve function. As naturally occurred in several plant and fungal sources and is most commonly present in the form of triglycerides. Commercially, a key active component of evening primrose oil and borage oil. Evening primrose oil typically contains approximately 7–14% GLA & was clinically studied for potential clinical applications, including menopausal symptoms, diabetic neuropathy, cyclical breast discomfort. As a result, GLA is commonly included in over-the-counter dietary supplements. Scientific studies had examined GLA's role across range of health areas, including inflammatory and immune-related conditions such as rheumatoid arthritis, atopic eczema, asthma, and ulcerative colitis, as well as metabolic and neurological conditions like cardiovascular disease, diabetic neuropathy, ADHD, osteoporosis, and sleep disturbances. We are a globally established Alpha Lipoic Acid and Gamma-Linolenic Acid supplier, along with a broad portfolio of nutraceutical ingredients worldwide through comprehensive regulatory documentation, (CoA) traceability, and consistent global supply capabilities, ensuring reliable lead times and quality assurance across all grades.
Gamolenic acid (GLA), or γ-linolenic acid or also known as ácido gamolénico (GLA borage oil manufacturer) is a biologically important omega-6 fatty acid. GLA bypasses (unlike many fatty acids) the delta-6-desaturase enzyme-frequently impaired due to aging, metabolic conditions, or chronic disease. GLA is efficiently converted into dihomo-gamma-linolenic acid (DGLA), a direct precursor to prostaglandin E1 (PGE1), a compound universally recognised for its anti-inflammatory and vasodilatory roles in the body. Endogenous production of GLA reduces in diabetes- (comprises cell membranes and impaired nerve signaling)-GLA supplementation provides essential structural lipids that help support nerve m...
Chemical Properties & Specifications
S26-S36
H315; H319; H335
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
May slow blood clotting; use caution with anticoagulant medications
On ALA Combination, Nerve blood flow and conduction velocity enhancement
Atopic Dermatitis treatment and Skin moisture retention
Manages symptoms of PMS and hormonal inflammation
Highly prone to oxidation
Store in a cool place under Nitrogen blanketing
Handle as a lipid/oil & ensure clean transfer to avoid rancidity
Storage shelf life 12-18 months (Cold-pressed oils may vary)
GLA) is a biologically active omega-6 fatty acid involved in inflammatory regulation, cellular signaling, and membrane structure. GLA is widely used in nutraceutical raw materials and gamma linolenic acid supplements due to its established biochemical functions.
GLA is considered a conditionally essential fatty acid. Although it can be synthesized from linoleic acid, this conversion depends on the delta-6-desaturase enzyme, which may be impaired by aging, diabetes, or metabolic disorders.
Gamma-linolenic acid metabolism involves rapid conversion of GLA into dihomo-gamma-linolenic acid (DGLA). DGLA is a direct prostaglandin E1 (PGE1) precursor, linking GLA to anti-inflammatory and vascular mechanisms.
Reduced delta-6-desaturase activity in diabetes can lower endogenous GLA levels, contributing to impaired nerve membrane integrity and altered nerve signaling. GLA supplementation has been studied for its role in supporting nerve health in diabetic neuropathy.
GLA borage oil Evening primrose oil GLA Black currant seed oil Fungal GLA sources produced via fermentation Among these, borage oil gamma linolenic acid contains the highest natural concentration.
Borage oil typically contains 20–25% gamma linolenic acid, making it the most concentrated commercial source of GLA omega-6 available for dietary supplements and pharmaceutical applications.
GLA is most commonly supplied in triglyceride form, standardized oil extracts, or encapsulated formats suitable for pharmaceutical-grade GLA and nutraceutical ingredient applications.
Clinical and preclinical studies have evaluated gamma linolenic acid in: Inflammatory conditions (rheumatoid arthritis, atopic eczema); Metabolic disorders (cardiovascular disease, diabetic neuropathy); Respiratory conditions (asthma, ARDS); Neurological and cognitive health (ADHD, insomnia); Bone and immune health (osteoporosis, ulcerative colitis).
Unlike linoleic acid, GLA fatty acid does not require delta-6-desaturase activation to exert biological effects. This makes GLA metabolically distinct within the omega-6 fatty acid category.
Yes, gamma linolenic acid supplements are widely available in OTC formulations, often derived from evening primrose oil, borage oil, or fungal fermentation sources.
GLA is available in food grade, nutraceutical grade, and pharmaceutical grade, depending on purity, regulatory standards, and intended application.
Yes, GLA global supply is well established for use in dietary supplements, functional foods, and pharmaceuticals, provided the ingredient meets local regulatory and quality requirements
Yes export ready with GLA CoA, GLA product specifications, Stability and shelf-life data, Regulatory and traceability documentation.
