Cabergoline CBG

CAS Number: 81409-90-7

Molecular Formula: C26H37N5O2

About Cabergoline CBG

Cabergoline is a dopamine receptor agonist derived from ergot alkaloids. It is used to inhibit prolactin secretion, making it effective for treating hyperprolactinemia, prolactinomas, and Parkinson’s disease. It is a long-acting dopamine D₂ receptor agonist that suppresses prolactin production by binding to dopaminergi...

Synonyms

1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Cabaser
Cabaseril
cabergoline

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Cabergoline CBG Specifications

CAS Number

81409-90-7

Molecular Formula

C26H37N5O2

IUPAC Name

(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Canonical SMILES

CCN(CCCN(C)C)C(=O)C1CN(CC=C)[C@@H]2C3=CC=CC=C3NC4=C2C1C=C4

InChI Key

1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

InChI

KORNTPPJEAJQIU-KJXAQDMKSA-N

CAS Number

81409-90-7

Molecular Formula

C26H37N5O2

IUPAC Name

(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Canonical SMILES

CCN(CCCN(C)C)C(=O)C1CN(CC=C)[C@@H]2C3=CC=CC=C3NC4=C2C1C=C4

InChI Key

1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

InChI

KORNTPPJEAJQIU-KJXAQDMKSA-N

Appearance

White to almost white crystalline powder

Solubility

Freely soluable in alchohol 96%

Specific optical rotation (on anhydrous basis)

-81℃

Water content

0.20%

Residue in ignition

0.05%

Heavy metals

< 220ppm

Residual solvent (n-heptane)

1400ppm

Residual solvent (Methyl tert-butyl ether)

550ppm

Assay (on anhydrous basis)

99.50%

GHS Classification

Acute Toxicity (Oral): Category 4 Skin Irritation: Category 2 Eye Irritation: Category 2A Specific Target Organ Toxicity (Single Exposure): Category 3

Hazard Statements

H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation

Precautionary Statements

P261: Avoid breathing dust/fume/gas/mist/vapors/spray. P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P301+P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. P302+P352: IF ON SKIN: Wash with plenty of water. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Medical Treatment

Used for hyperprolactinemia, prolactinomas, and Parkinson’s disease

Endocrinology

Helps suppress excess prolactin secretion in patients with hormonal imbalances.

Temperature

Store at 2–8°C (36–46°F)

Environment

Keep in a cool, dry place, protected from light and moisture.

Protection

Store in tightly sealed, light-resistant containers.

Packaging Options

Available in 1 mg, 5 mg, and 10 mg tablet forms, packaged in blister packs or HDPE bottles.

COA

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1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Cabaser
Cabaseril
cabergoline