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4-(4-Methylphenoxy)benzylamine hydrochloride (CAS 262862-66-8), commonly referred to as TOBA HCl, is a high-purity aromatic amine salt. In Elemental Derivatives and Pharmaceutical hierarchy, it serves as the indispensable structural building block for the synthesis of Vortioxetine (an atypical antidepressant). TOBA HCl's architecture, featuring a phenoxyphenyl core and a terminal primary amine, makes it a critical node for N-arylation reactions in the production of multi-modal serotonergic agents. Our bulk TOBA HCl is manufactured under stringent quality controls, ensuring low impurity profiles and high crystalline stability for CDMO and large-scale API manufacturing. As a critical aromatic amine intermediate, it offers exceptional regioselectivity in palladium-catalysed coupling reactions. Whether you are developing next-generation CNS therapies or advanced agrochemical actives, our TOBA HCl provides the consistent performance and reliable lead times required for global supply chain excellence.
4-(4-Methylphenoxy)benzylamine hydrochloride (CAS 262862-66-8), commonly referred to as TOBA HCl, is a high-purity aromatic amine salt. In Elemental Derivatives and Pharmaceutical hierarchy, it serves as the indispensable structural building block for the synthesis of Vortioxetine (an atypical antidepressant). TOBA HCl's architecture, featuring a phenoxyphenyl core and a terminal primary amine, makes it a critical node for N-arylation reactions in the production of multi-modal serotonergic agents. Our bulk TOBA HCl is manufactured under stringent quality controls, ensuring low impurity profiles and high crystalline stability for CDMO and large-scale API manufacturing. As a critical aromatic ...
Chemical Properties & Specifications
Phenoxyphenyl-methylamine scaffold - privileged structure in the development of novel Fungicides and Herbicides that target specific enzyme sites in plant pathogens, utilizing the ether-linked aromatic rings for optimized lipophilicity
Significant in Synthesis of Vortioxetine Hydrobromide. TOBA HCl-coupled with 2-(2,4-dimethylphenylthio)benzene derivatives to form the core of the antidepressant molecule
Functionalizing agent in the creation of specialized polymers and resins where an aromatic ether-linked amine moiety is required to enhance thermal or chemical resistance
Stable under recommended storage conditions
Sensitive to prolonged exposure to air and moisture which may lead to carbonate formation of the amine
Store in a cool, dry, well-ventilated area. Keep containers tightly closed
Recommended storage temperature: 15°C to 25°C