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1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone, commonly known as Keto Sulfone, is a synthetic intermediate and impurity associated with the production of Etoricoxib, a selective COX-2 inhibitor. It is used in pharmaceutical quality control to ensure drug purity and compliance with regulatory standards. It is also called as 2-(4-Methanesulfonyl phenyl) 1-(6-Methylpyridine-3-yl)-ethan-1-one.
1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone, commonly known as Keto Sulfone, is a synthetic intermediate and impurity associated with the production of Etoricoxib, a selective COX-2 inhibitor. It is used in pharmaceutical quality control to ensure drug purity and compliance with regulatory standards. It is also called as 2-(4-Methanesulfonyl phenyl) 1-(6-Methylpyridine-3-yl)-ethan-1-one.
Chemical Properties & Specifications
Classification according to Regulation (EC) No 1272/2008
Supplemental
No hazard identified
General advice-Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled, If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact-Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed -Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Personal precautions, protective equipment and emergency procedures-Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Do not let product enter drains.
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection
Used as an impurity reference standard in the manufacturing and quality control of Etoricoxib API and finished formulations.
Employed in the validation of HPLC and other analytical methods for impurity profiling.
Used in drug discovery and impurity profiling studies related to COX-2 inhibitors and anti-inflammatory compounds.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Hygroscopic.
Customised and also Available in 10 mg, 50 mg, 100 mg packs for laboratory use
Used as an impurity reference standard for the quality control of Etoricoxib, ensuring compliance with pharmacopeial standards and regulatory requirements.
It allows pharmaceutical companies to identify and quantify impurities, ensuring the purity, safety, and efficacy of Etoricoxib drug products during manufacturing and stability testing.
High-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and gas chromatography-mass spectrometry (GC-MS) are commonly used for the detection and quantification of this impurity.
Yes, it is stable when stored in a cool, dry place away from light and moisture. Proper storage ensures long-term stability for accurate analytical testing.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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