1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone)

1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone)

CAS Number
221615-75-4
Molecular Formula
C15H15NO3S
Purity
99.48%
Etoricoxib intermediateEnd API: Etoricoxib

About 1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone)

1-(6-Methyl-3-pyridinyl)-2-(4-methylsulfonyl)phenyl ethanone, commonly known as Keto Sulfone, is a synthetic intermediate and impurity associated with the production of Etoricoxib, a selective COX-2 inhibitor. It is used in pharmaceutical quality control to ensure drug purity and compliance with regulatory standards. I...

1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone) Specifications

CAS Number
221615-75-4
Molecular Formula
C15H15NO3S
IUPAC NameORBotanical Name
1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone
Canonical SMILES
CC1=NC=C(C=C1)C(C2=CC=C(C=C2)S(=O)(=O)C)=O
InChI Key
YBFHILNBYXCJKD-UHFFFAOYSA-N
InChI
1S/C15H15NO3S/c1-11-3-6-13(10-16-11)15(17)9-12-4-7-14(8-5-12)20(2,18)19/h3-8,10H,9H2,1-2H3
MDL Number
MFCD11110696
UNSPSC Code
12352100
eClass
32039000
NACRES
NA.24
HSN No
2933.39.90
Appearance
Pale Yellow Powder Crystalline powder
Loss on drying
0.34%
Purity
99.48%
Assay on dried basis (hplc)
100.3%
Shelf Life
2 years
Hazards identification
Classification according to Regulation (EC) No 1272/2008
Precautionary statement(s)
Supplemental
Hazard Statement(s)
No hazard identified
First aid measures
General advice-Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled, If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact-Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed -Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Accidental release measures
Personal precautions, protective equipment and emergency procedures-Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materialsfor containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Personal protective equipment Eye/faceprotection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection

Pharmaceutical Industry

Used as an impurity reference standard in the manufacturing and quality control of Etoricoxib API and finished formulations.

Analytical Laboratories

Employed in the validation of HPLC and other analytical methods for impurity profiling.

Research & Development

Used in drug discovery and impurity profiling studies related to COX-2 inhibitors and anti-inflammatory compounds.

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Hygroscopic.

Packaging Options

Customised and also Available in 10 mg, 50 mg, 100 mg packs for laboratory use

1-(6-Methyl-3-pyridinyl)-2-(4-methyl sulfonyl) phenyl ethanone (keto Sulfone) FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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