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Venlafaxine Hydrochloride (CAS NO : 99300-78-4)

Venlafaxine Hydrochloride is a synthetic antidepressant belonging to the serotonin-norepinephrine reuptake inhibitor (SNRI) class. Also known as VENLAFAXINE HCl by manufacturers and fundamentally used to treat major depressive disorder, generalized anxiety disorder and panic disorder. Venlafaxine is a racemic mixture of two enantiomers structurally, each contributing to its pharmacological activity. The Venlafaxine compound is well-absorbed orally and extensively metabolized in the liver, with its active metabolite, O-desmethylvenlafaxine (ODV), also contributing to its therapeutic effects. Venlafaxine supplier employee it in the production of oral dosage forms such as tablets and extended-release capsules, Venlafaxine Hydrochloride serves as the active ingredient in antidepressant medications prescribed for various mood and anxiety disorders. Venlafaxine is Second-Generation SNRI; Dual-Action Antidepressant; Racemic API for CNS Applications. Venlafaxine plant have ISO 45001 2018, ISO 9001 2015, ISO 14001 2015 certifications.

Venlafaxine Hydrochloride

Venlafaxine Hydrochloride is a synthetic antidepressant belonging to the serotonin-norepinephrine reuptake inhibitor (SNRI) class. Also known as VENLAFAXINE HCl by manufacturers and fundamentally used to treat major depressive disorder, generalized anxiety disorder and panic disorder. Venlafaxine is a racemic mixture of two enantiomers structurally, each contributing to its pharmacological activity. The Venlafaxine compound is well-absorbed orally and extensively metabolized in the liver, with its active metabolite, O-desmethylvenlafaxine (ODV), also contributing to its therapeutic effects. Venlafaxine supplier employee it in the production of oral dosage forms such as tablets and extended-release capsules, Venlafaxine Hydrochloride serves as the active ingredient in antidepressant medications prescribed for various mood and anxiety disorders. Venlafaxine is Second-Generation SNRI; Dual-Action Antidepressant; Racemic API for CNS Applications. Venlafaxine plant have ISO 45001 2018, ISO 9001 2015, ISO 14001 2015 certifications.

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Pharmaceutical Actives & Precursors

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Active Pharmaceutical Ingredients (APIs)

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Chemical Properties & Specifications

Applications of Venlafaxine Hydrochloride

Treatment of (MDD)

Used as a frontline antidepressant in the management of Major Depressive Disorder by enhancing the availability of serotonin and norepinephrine in the central nervous system.

Management of (GAD)

Helps reduce excessive worry and tension associated with Generalized Anxiety Disorder, offering long-term relief with minimal sedative effects.

Relief from (SAD)

Prescribed for individuals with persistent social fear or avoidance, improving social interaction and quality of life.

Control of Panic Disorder

Reduces the frequency and intensity of panic attacks by regulating neurotransmitter activity in the brain.

Formulation in Oral Extended-Release Products

Commonly formulated in extended-release tablets or capsules for once-daily dosing, improving patient compliance.

Pharmacokinetics

High oral bioavailability with extensive hepatic metabolism to active metabolite ODV.

Protein Binding

Approximately 27% for parent compound; 30% for ODV .

Elimination Half-Life

5±2 hours for immediate-release; 15±6 hours for extended-release formulations.

Excretion

Predominantly renal, with 87% excreted in urine (5% unchanged drug; 29% as ODV; 53% as other metabolites) .

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