Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Itraconazole or Oriconazole is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Manufacturers named Itraconazole as (Itrizole), which is also a member of the triazoles class, dioxolane, N-arylpiperazine, dichlorobenzene, cyclic ketal, and aromatic ether. Derived from cis-ketoconazole, Itraconazole's imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group, and the acetyl group on the piperazine moiety is substituted by a p-[(±)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. ECHA deprecated cas number is 84604-65-9 for Itraconazole. Itraconazole is specifically FDA Approved and is in WHO Essential Medicines List.
Itraconazole is a triazole-class antifungal agent used to treat a variety of fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Itraconazole or Oriconazole is effective against a broad spectrum of fungi, including Aspergillus, Blastomyces, Histoplasma, and Candida species. Manufacturers named Itraconazole as (Itrizole), which is also a member of the triazoles class, dioxolane, N-arylpiperazine, dichlorobenzene, cyclic ketal, and aromatic ether. Derived from cis-ketoconazole, Itraconazole's imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group, and the acetyl group on the piperazine moiety is substituted by a p-[(±)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. ECHA deprecated cas number is 84604-65-9 for Itraconazole. Itraconazole is specifically FDA Approved and is in WHO Essential Medicines List.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
Acute Toxicity (Oral): Category 4 Skin Irritation: Category 2 Eye Irritation: Category 2A Specific Target Organ Toxicity (Single Exposure): Category 3
H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
P261: Avoid breathing dust/fume/gas/mist/vapors/spray. P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P301+P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. P302+P352: IF ON SKIN: Wash with plenty of water. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
Used to treat systemic and superficial fungal infections, including aspergillosis, blastomycosis, histoplasmosis, and onychomycosis.
Effective in treating dermatophytoses and other cutaneous fungal infections
Ensures prolonged circulation time and sustained therapeutic levels.
Available in multiple formulations to suit different treatment needs.
Aspergillosis, blastomycosis, histoplasmosis Oral treatments for systemic fungal infections Cosmetic formulations aimed at improving hair growth (in some formulations)
Onychomycosis
Systemic fungal infections
Aimed at improving hair growth (in some formulations)
Store at 15–25°C (59–77°F).
Keep in a cool, dry place, protected from light and moisture.
Store in tightly sealed, light-resistant containers.
Available in 100 mg capsules, oral solutions, and topical formulations, packaged in blister packs or bottles.
