1-(2,4-Diflourophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone (DFTA) (CAS NO : 86404-63-9)

1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone, commonly referred to as DFTA, is an intermediate in the synthesis of Fluconazole and other azole-based antifungal medications. It is used in pharmaceutical manufacturing and research & development as part of the chemical pathway to producing COX-2 inhibitors and related therapeutic agents.

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Pharmaceutical

Sub-category

Intermediates & Precursors

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Chemical Properties & Specifications

Applications of 1-(2,4-Diflourophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone (DFTA)

Pharmaceutical Industry

Used as an intermediate in the synthesis of Fluconazole and related compounds.

Research & Development

Employed in the development of triazole-based antifungal agents and other bioactive molecules.

Have Questions About 1-(2,4-Diflourophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone (DFTA)?
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What is the primary use of 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone in pharmaceuticals?

DFTA is an intermediate used in the synthesis of Fluconazole and other azole-based antifungal medications. It is an essential compound in the production of COX-2 inhibitors and other therapeutic agents.

How does 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone contribute to the synthesis of Fluconazole?

It acts as a precursor in the synthesis of Fluconazole, providing a triazole ring system that is integral to the bioactive structure of the drug, a potent antifungal agent.

Is 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone safe to handle in a laboratory?

Yes, it should be handled with care. Use appropriate PPE (personal protective equipment) including gloves, goggles, and lab coats to avoid skin and eye contact. Follow standard laboratory safety protocols when working with this compound.

What analytical techniques are commonly used to detect 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)-ethanone?

High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) are commonly used for detecting and quantifying DFTA in pharmaceutical formulations and ensuring the purity of Fluconazole.