

Our N,N-Carbonyldiimidazole (CDI) is a high-purity white crystalline reagent engineered to activate carboxylic acids for nucleophilic substitution. Acting as a safer, solid alternative to highly toxic phosgene, CDI facilitates clean reactions by releasing only CO₂ and imidazole as relatively innocuous by-products. In 2026, it is the preferred choice for "Green Chemistry" applications because it eliminates the need for corrosive acid chlorides or strong auxiliary bases, significantly reducing side reactions and simplifying purification. We provide high-stability grades with 99%+ purity, specifically designed to maintain activity in anhydrous environments for critical API, peptide manufacturing, peptide synthesis, protein modification, and pharmaceutical research. Plays a highly crucial role in the synthesis of nucleic acid derivatives and other complex organic molecules. We are a global manufacturer of N,N-carbonyl diimidazole, specialised in producing high-purity (98.97%) CDI with large-scale production capacity, ensuring reliable lead times; comprehensive regulatory documentation (CoA); and consistent worldwide supply capabilities across all grades/forms/purity.

Our N,N-Carbonyldiimidazole (CDI) is a high-purity white crystalline reagent engineered to activate carboxylic acids for nucleophilic substitution. Acting as a safer, solid alternative to highly toxic phosgene, CDI facilitates clean reactions by releasing only CO₂ and imidazole as relatively innocuous by-products. In 2026, it is the preferred choice for "Green Chemistry" applications because it eliminates the need for corrosive acid chlorides or strong auxiliary bases, significantly reducing side reactions and simplifying purification. We provide high-stability grades with 99%+ purity, specifically designed to maintain activity in anhydrous environments for critical API, peptide manufacturin...

Chemical Properties & Specifications
H302, H315, H319, H332
P261, P280, P304 + P340
Acute toxicity, oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
6.1B - Harmful substance, not a primary fire risk
Primary coupling agent for amino acid activation with minimal racemisation
Essential for the synthesis of antibiotics, anti-inflammatory drugs, and complex bioconjugates
Converts amines into ureas and carbamates, and alcohols into esters
Facilitates the activation of phosphates and the synthesis of nucleic acid derivatives
Cross-linking agents & for surface functionalisation in advanced material science
Store at 20–25°C (68–77°F).
Keep in a cool, dry place away from light and moisture.
Use airtight containers to prevent contamination and degradation.
Bulk Quantities: Available in bulk for industrial and research use, typically ranging from 1 kg to 100 kg containers.