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Lamotrigine

Lamotrigine

CAS Number: 84057-84-1

Molecular Formula: C9H7Cl2N5

Phenyltriazine DerivativeVoltage Gated Sodium Channel BlockerMulti-regimen compatibilityTherapeutic category: AntiepilepticUS FDA Approved APIEU EMA Approved Shared SPCIndia DCGI Approved

About Lamotrigine

Lamotrigine is a broad-spectrum antiepileptic drug (AED) that belongs to the phenyltriazine class. It acts by inhibiting voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing excitatory neurotransmitter release, particularly glutamate. This mechanism provides efficacy across a variety of se...

Synonyms

  • 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
  • 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine
  • BW 430C
  • BW-430C
  • BW430C
View all

Lamotrigine Specifications

CAS Number
84057-84-1
Molecular Formula
C9H7Cl2N5
Molecular Weight
256.09 g/mol
IUPAC Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Canonical SMILES
NC1=NC(N)=NN=C1C2=CC=CC(Cl)=C2Cl
InChI Key
PYZRQGJRPPTADH-UHFFFAOYSA-N
EINECS Number
281-901-8
UNSPSC Code
41116107
HSN No
29336990
Physical State
White to cream crystalline powder
Melting Point
177–181 °C
Protein Binding
~55%
Bioavailability
~98%
Molecular Weight
256.09 g/mol
GHS Classification
Acute oral toxicity (Category 3), Irritant (skin/eye)
Precautionary Statement Codes
P201, P260, P264, P280, P301+P310, and P321
Hazard Classes and Categories
Acute Tox. 3 (100%) Skin Sens. 1 (100%)

Antiepileptic & Mood Stabilizing API

Used in the manufacture of oral dosage forms to treat focal seizures, generalized tonic-clonic seizures, and Lennox–Gastaut syndrome. Also utilized as a long-term mood stabilizer in bipolar I disorder.

Broad CNS Efficacy

Effective across multiple seizure types and bipolar disorder

High Oral Bioavailability

≥98% absorption with minimal first-pass metabolism

Long Elimination Half-Life

24–35 hours, supporting once-daily dosing in many cases

Low Drug Interaction Potential

Not a CYP inducer or inhibitor

Chemically Stable

Resistant to hydrolysis and oxidation under standard conditions

Antiepileptic Agent

A primary medication used as monotherapy or adjunctive therapy for the management of partial seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome in both adult and pediatric populations

Mood Stabilizer

A critical therapeutic agent utilized for maintenance treatment of bipolar I disorder to delay the occurrence of mood episodes, such as depression, mania, or hypomania, by stabilizing neuronal membranes

Sodium Channel Blocker

A specialized research tool employed in electrophysiological studies to investigate the inhibition of voltage-gated sodium channels and the subsequent reduction of excitatory neurotransmitter release like glutamate and aspartate

Pharmaceutical Intermediate

A functionalized triazine derivative used as a building block in the synthesis of complex medicinal compounds and active pharmaceutical ingredients within academic and industrial drug development.

Storage Conditions

Store at 2–8 °C in tightly sealed, light-resistant containers

Shelf Life

Stable at 2–8 °C; shelf life ≥ 2 years under recommended condition

Packaging Options

Available in HDPE drums or fiberboard containers with double PE liners; sampling in 100 g – 1 kg aluminum bottles

Transport Classification

Non-hazardous; not regulated under IMDG/IATA

  1. 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
  2. 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine
  3. BW 430C
  4. BW-430C
  5. BW430C

Lamotrigine FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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