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Cabergoline is a dopamine receptor agonist derived from ergot alkaloids. It is used to inhibit prolactin secretion, making it effective for treating hyperprolactinemia, prolactinomas, and Parkinson’s disease. It is a long-acting dopamine D₂ receptor agonist that suppresses prolactin production by binding to dopaminergic receptors in the pituitary gland. Cabergoline contains NLT 98.0% and NMT 102.0% of cabergoline, calculated on the anhydrous basis for the crystalline form and on the anhydrous and solvent-free basis for the amorphous form. 1-Ethyl-3-[3-(dimethylamino)propyl]-3-[[(6aR,9R,10aR)-7-(prop-2-enyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]carbonyl]urea, corresponds to Cabergoline and 1-[(6-Allylergolin-8β-yl)-carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea is an alternative representation of its chemical structure.
Cabergoline is a dopamine receptor agonist derived from ergot alkaloids. It is used to inhibit prolactin secretion, making it effective for treating hyperprolactinemia, prolactinomas, and Parkinson’s disease. It is a long-acting dopamine D₂ receptor agonist that suppresses prolactin production by binding to dopaminergic receptors in the pituitary gland. Cabergoline contains NLT 98.0% and NMT 102.0% of cabergoline, calculated on the anhydrous basis for the crystalline form and on the anhydrous and solvent-free basis for the amorphous form. 1-Ethyl-3-[3-(dimethylamino)propyl]-3-[[(6aR,9R,10aR)-7-(prop-2-enyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]carbonyl]urea, corresponds t...
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Acute Toxicity (Oral): Category 4 Skin Irritation: Category 2 Eye Irritation: Category 2A Specific Target Organ Toxicity (Single Exposure): Category 3
H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapors/spray. P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P301+P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. P302+P352: IF ON SKIN: Wash with plenty of water. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
Used for hyperprolactinemia, prolactinomas, and Parkinson’s disease
Helps suppress excess prolactin secretion in patients with hormonal imbalances.
Store at 2–8°C (36–46°F)
Keep in a cool, dry place, protected from light and moisture.
Store in tightly sealed, light-resistant containers.
Available in 1 mg, 5 mg, and 10 mg tablet forms, packaged in blister packs or HDPE bottles.
It is used to treat conditions caused by high prolactin levels, such as menstrual problems, infertility, and prolactinomas.
Cabergoline is a dopamine agonist that mimics dopamine and reduces prolactin secretion in the pituitary gland.
Common side effects include nausea, headache, dizziness, and fatigue.
Consult a healthcare provider, as it should only be used during pregnancy if medically necessary.
The duration varies per patient, follow your doctor’s instructions for length of use.
It is usually taken twice weekly with or without food, as directed by a doctor.
Avoid alcohol, driving, or operating machinery until you understand how it affects you.
Prolactin levels typically decrease within 3 hours of dosing, with effects lasting up to 2 weeks.
UNII-LL60K9J05T KEGG Drug ID- D00987 ChEBI ID- 3286 ChEMBL ID- 1201087
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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