2,4-Dihydro-4-[4-[4-(4- hydroxyphenyl)-1- piperazinyl]phenyl]-2-(1- methylpropyl)-3H-1,2,4-triazole-3- one (IT-7) (CAS NO : 106461-41-0)

2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one, commonly known as IT-7, is an intermediate compound in the synthesis of Itraconazole, an antifungal medication. IT-7 plays a crucial role in the pharmaceutical manufacturing process of Itraconazole, contributing to its efficacy in treating fungal infections.

Industries

Pharmaceutical

Sub-category

Intermediates & Precursors

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Chemical Properties & Specifications

Applications of 2,4-Dihydro-4-[4-[4-(4- hydroxyphenyl)-1- piperazinyl]phenyl]-2-(1- methylpropyl)-3H-1,2,4-triazole-3- one (IT-7)

Pharmaceutical Synthesis

Serves as a key intermediate in the production of Itraconazole, facilitating the construction of its complex triazole ring structure.

Research and Development:

Utilized in the development of antifungal agents, aiding in the study of triazole derivatives and their biological activities.

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What is 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one (IT-7) used for?

IT-7 is primarily used as a pharmaceutical intermediate in the synthesis of Itraconazole, a widely used antifungal medication. It plays a crucial role in the chemical synthesis of triazole compounds, including the development of Itraconazole.

How is IT-7 used in pharmaceutical synthesis?

IT-7 is used as an intermediate compound to facilitate the creation of the triazole ring structure in the production of Itraconazole, helping to form the molecular scaffold for the active pharmaceutical ingredient.

Is IT-7 safe to handle?

When handled with appropriate safety precautions, IT-7 is safe to use in chemical research and pharmaceutical synthesis. Protective equipment such as gloves, goggles, and lab coats should be worn to avoid skin or eye contact.

What is the shelf life of IT-7?

IT-7 remains stable for several years if stored under controlled conditions (cool, dry, and away from heat and moisture), ensuring it maintains its effectiveness for pharmaceutical applications.