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1-(3-Dimethylaminopropyl)-3-Ethyl Carbodiimide Hydrochloride (EDAC·HCl) is a carbodiimide reagent widely used as a coupling agent in peptide synthesis and in conjugation reactions. It works by activating carboxyl groups on amino acids and facilitating the formation of peptide bonds. EDAC·HCl is particularly important in the creation of biomolecule conjugates, such as when linking haptens to proteins or polypeptides. Additionally, it is used in immobilizing biomolecules for various research applications, including the development of biosensors. Also called (1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride)
1-(3-Dimethylaminopropyl)-3-Ethyl Carbodiimide Hydrochloride (EDAC·HCl) is a carbodiimide reagent widely used as a coupling agent in peptide synthesis and in conjugation reactions. It works by activating carboxyl groups on amino acids and facilitating the formation of peptide bonds. EDAC·HCl is particularly important in the creation of biomolecule conjugates, such as when linking haptens to proteins or polypeptides. Additionally, it is used in immobilizing biomolecules for various research applications, including the development of biosensors. Also called (1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride)
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Harmful if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause damage to organs through prolonged or repeated exposure.
Wash face, hands and any exposed skin thoroughly after handling. Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. Contaminated work clothing should not be allowed out of the workplace. Do not breathe dust/fume/gas/mist/vapors/spray.
EDAC·HCl is extensively used to activate carboxyl groups in peptides, enabling the formation of peptide bonds between amino acids, facilitating the synthesis of peptides and proteins.
It is used to link haptens to carrier proteins, making it essential in the preparation of vaccines and in various immunoassays.
When combined with N-Hydroxysuccinimide (NHS), EDAC·HCl is used for immobilizing biomolecules onto solid supports, which is essential in the fabrication of biosensors and affinity chromatography applications.
Store locked up. Keep container tightly closed in a dry and well-ventilated place. To maintain product quality: Keep refrigerated. Store under an inert atmosphere. Incompatible Materials. Acids. Oxidizing agent.
Wear personal protective equipment/face protection. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek immediate medical assistance.
Available in various sizes, including 25g, 100g, 500g, and 1kg, suitable for laboratory and industrial applications.
EDAC·HCl activates the carboxyl group of an amino acid, facilitating the formation of a peptide bond with the amine group of another amino acid, essential for peptide synthesis.
EDAC·HCl is often preferred for aqueous peptide synthesis because of its water solubility, making it more versatile and safer for various biological applications compared to other coupling agents.
Yes, EDAC·HCl is scalable for industrial peptide synthesis and is commonly used in biotech manufacturing for the production of biologics, vaccines, and therapeutic peptides.
Yes, EDAC·HCl is frequently used with NHS (N-Hydroxysuccinimide) for enhanced coupling efficiency and minimal side reactions in peptide and biomolecule conjugation.
While EDAC·HCl is a powerful coupling agent, it should be handled with appropriate protective gear, including gloves, goggles, and lab coats, as it can cause skin and eye irritation.
EDAC·HCl is commonly used in the synthesis of peptides and the production of biomolecule conjugates, such as in immunotherapy and vaccine development.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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