Search through
Methyl 3-Aminocrotonate (CAS No: 14205-39-1) functions as a fundamental β-enamino ester building block, predominantly utilised in the Hantzsch dihydropyridine synthesis to produce critical 1,4-dihydropyridine (1,4-DHP) calcium channel blockers such as Amlodipine, Nifedipine, and Felodipine. Beyond its established role in cardiovascular pharmacopeia, this versatile intermediate is increasingly sought for the synthesis of complex nitrogen-containing heterocycles, including substituted pyridines and pyrimidines, which are essential for novel agrochemical active ingredients and specialty fine chemicals. Current market dynamics reflect a shift toward high-purity grades, typically ≥98%, to meet the stringent quality assurance requirements of global CDMOs and pharmaceutical manufacturers. As a globally established Methyl 3-Aminocrotonate supplier with ≥98% purity, we ensure dependable supply, consistent quality, and complete regulatory documentation, including Methyl 3-Aminocrotonate CoA and Methyl 3-Aminocrotonate TDS across all grades. Beyond supply, we support partners through the entire product lifecycle from route scouting, process and formulation development, and analytical method development to scale-up, process optimisation, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and global supply chain and logistics coordination.
Methyl 3-Aminocrotonate (CAS No: 14205-39-1) functions as a fundamental β-enamino ester building block, predominantly utilised in the Hantzsch dihydropyridine synthesis to produce critical 1,4-dihydropyridine (1,4-DHP) calcium channel blockers such as Amlodipine, Nifedipine, and Felodipine. Beyond its established role in cardiovascular pharmacopeia, this versatile intermediate is increasingly sought for the synthesis of complex nitrogen-containing heterocycles, including substituted pyridines and pyrimidines, which are essential for novel agrochemical active ingredients and specialty fine chemicals. Current market dynamics reflect a shift toward high-purity grades, typically ≥98%, to meet th...
Chemical Properties & Specifications
A key intermediate used for the synthesis of various pharmaceuticals, particularly dihydropyridine-type calcium channel blockers such as nifedipine, amlodipine, and nitrendipine used to treat cardiovascular diseases
An unsaturated ester compound used as a versatile intermediate in organic chemistry for the development of novel compounds, nitrogen-containing heterocycles like pyridines and pyrimidines, and for the synthesis of amino acids and peptides
A chemical intermediate utilized in the formulation and synthesis of agrochemicals to enhance crop protection and yield
A compound explored for use in the creation of specialty polymers and as a manufacture stabilizer for plastics
A reagent used in research to study enzyme activity and metabolic pathways to provide insights into biological processes
Methyl 3-aminocrotonate is an off-white to yellowish crystalline solid that serves as a versatile intermediate in organic synthesis and pharmaceutical chemistry. It is primarily used as a key precursor in the synthesis of 1,4-dihydropyridine-type calcium channel blockers, such as nifedipine, nitrendipine, and amlodipine, which are used to treat hypertension. What industries commonly use this Methyl 3-Aminocrotonate?: This compound is widely utilized in the pharmaceutical, agrochemical, and polymer industries for the production of medicines, pesticides, stabilizers, and specialty plastics. What formulation types is this ingredient compatible with?: It is insoluble in water but soluble in organic solvents like chloroform, acetone, anhydrous ether, and pyridine, and it is often used in liquid-phase or solid-state organic synthesis protocols. What analytical specifications are provided?: Standard specifications include CAS number 14205-39-1, a minimum purity of 98% or 99%, and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents. Do you support global supply and logistics?: Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time. Is Methyl 3-Aminocrotonate export ready and what is the MOQ?: The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pyridine
Sub-Category : Aminopyridines & Functionalized Pyridines
Description : Pyridine-2-amine CAS 504-29-0 is a fundamental building block in the API intermediates market, prima...
Category : Bromine
Sub-Category : Bromo-Functional Acids & Esters
Description : Ethyl 8-bromooctanoate (CAS No: 29823-21-0) serves as a sophisticated bifunctional building block in...
Category : Halogen Derivatives
Sub-Category : Iodo/Fluoro-Functional Intermediates
Description : 2-Chloro-5-iodobenzoic acid (CAS No: 19094-56-5) serves as a critical bifunctional aromatic building...
Category : Pyridine
Sub-Category : Halogenated Pyridines
Description : 2-Chloropyridine CAS 109-09-1 serves as a high-purity fine chemical with 99% purity essential for th...
