N,N Carbonyl diimidazole (CDI) (CAS NO : 530-62-1)

N,N'-Carbonyl diimidazole (CDI) is an organic reagent primarily used in peptide synthesis, protein modification, and pharmaceutical research. It serves as a coupling reagent in peptide bond formation, promoting the reaction between amines and carboxylic acids. CDI is widely used in chemical manufacturing, particularly in the creation of bioconjugates, owing to its efficiency in activating carboxyl groups. It also plays a crucial role in the synthesis of nucleic acid derivatives and other complex organic molecules

Industries

Pharmaceutical

Sub-category

Reagents

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Chemical Properties & Specifications

Applications of N,N Carbonyl diimidazole (CDI)

Pharmaceuticals

Used in peptide synthesis, especially for the coupling of amino acids in the formation of peptides and proteins.

Chemical Manufacturing

Serves as a reagent in the synthesis of bioconjugates and nucleic acid derivatives.

Research and Development

Utilized in organic synthesis, particularly in modifying biomolecules for various chemical applications.

Have Questions About N,N Carbonyl diimidazole (CDI)?
We've Got Answers.

What is N,N'-Carbonyl Diimidazole (CDI) used for?

CDI is a widely used reagent in organic synthesis, particularly for peptide coupling, nucleoside activation, and esterification reactions. It is also employed in pharmaceutical and agrochemical industries.

How does CDI work as a coupling agent?

CDI acts as a dehydrating agent, facilitating the formation of amide, ester, and carbamate bonds by activating carboxyl groups for nucleophilic attack.

What safety precautions should be taken when handling CDI?

CDI is highly reactive and should be handled with protective gloves and eyewear. It should be stored in a cool, dry place away from moisture and strong acids.

Can CDI be used in large-scale industrial applications?

Yes, CDI is commonly used in large-scale synthesis of pharmaceuticals, agrochemicals, and specialty chemicals due to its efficiency in coupling reactions.

What are the advantages of using CDI over other coupling agents?

CDI is preferred due to its high reactivity, minimal side products, and compatibility with various solvents, making it an efficient and clean reagent for organic synthesis.