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N,N Carbonyldiimidazole (CDI) is a high-purity carbonyl activating agent and organic coupling reagent widely used in pharmaceutical, biotechnology, and specialty chemical manufacturing. Chemically classified as a carbonyl diimidazole compound, it functions by activating carboxylic acids to form reactive imidazolide intermediates, enabling efficient amide, ester, carbamate, and urea bond formation under mild conditions without direct biological receptor interaction. Extensively applied in peptide synthesis, API and advanced intermediate production, protein modification, bioconjugation, and nucleic acid derivative synthesis, CDI serves as a synthetic reagent rather than a therapeutic substance. Supplied as a white to off-white crystalline solid, it offers high selectivity, controlled reactivity, and moisture-sensitive physicochemical properties suitable for regulated environments. Each batch undergoes comprehensive quality control including assay, melting range, and impurity profiling, and is supported with Certificate of Analysis (CoA), Safety Data Sheet (SDS), and full traceability documentation. As an established manufacturers and suppliers of N,N Carbonyl diimidazole in the USA, we ensure scalable supply from R&D to commercial volumes with consistent batch performance and reliable lead times with competitive prices (USD).
N,N Carbonyldiimidazole (CDI) is a high-purity carbonyl activating agent and organic coupling reagent widely used in pharmaceutical, biotechnology, and specialty chemical manufacturing. Chemically classified as a carbonyl diimidazole compound, it functions by activating carboxylic acids to form reactive imidazolide intermediates, enabling efficient amide, ester, carbamate, and urea bond formation under mild conditions without direct biological receptor interaction. Extensively applied in peptide synthesis, API and advanced intermediate production, protein modification, bioconjugation, and nucleic acid derivative synthesis, CDI serves as a synthetic reagent rather than a therapeutic substance...
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
H302, H315, H319, H332
P261, P280, P304 + P340
Acute toxicity, oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
6.1B - Harmful substance, not a primary fire risk
Primary coupling agent for amino acid activation with minimal racemisation
Essential for the synthesis of antibiotics, anti-inflammatory drugs, and complex bioconjugates
Converts amines into ureas and carbamates, and alcohols into esters
Facilitates the activation of phosphates and the synthesis of nucleic acid derivatives
Cross-linking agents & for surface functionalisation in advanced material science
Store at 20–25°C (68–77°F).
Keep in a cool, dry place away from light and moisture.
Use airtight containers to prevent contamination and degradation.
Bulk Quantities: Available in bulk for industrial and research use, typically ranging from 1 kg to 100 kg containers.
CDI is a widely used reagent in organic synthesis, particularly for peptide coupling, nucleoside activation, and esterification reactions. It is also employed in pharmaceutical and agrochemical industries.
CDI acts as a dehydrating agent, facilitating the formation of amide, ester, and carbamate bonds by activating carboxyl groups for nucleophilic attack.
CDI is highly reactive and should be handled with protective gloves and eyewear. It should be stored in a cool, dry place away from moisture and strong acids.
Yes, CDI is commonly used in large-scale synthesis of pharmaceuticals, agrochemicals, and specialty chemicals due to its efficiency in coupling reactions.
CDI is preferred due to its high reactivity, minimal side products, and compatibility with various solvents, making it an efficient and clean reagent for organic synthesis.
Phosgene is a highly toxic gas that is difficult to handle and store. CDI is a stable crystalline solid that performs similar acylation chemistry but is far easier to measure and dispense. Furthermore, CDI reactions generate C'O2 and imidazole as the only byproducts, which are non-toxic and easily removed during aqueous workup.
Major manufacturing hubs in Mumbai, Ankleshwar, and Hyderabad typically offer a lead time of 1 week or less for domestic orders, providing a significant advantage over the 10–14 week wait times often seen for imported specialty reagents.
Cdi mo1 along with CDI 99% Price March 2026 India shared upon sourcing with cdi coa, msds, tds with regulatory documentations attached with assured lead times.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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