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Ambrettolide (CAS No: 28645-51-4) is increasingly utilized by North American flavor and fragrance houses as a high purity fine chemicals building block, valued for its sophisticated macrocyclic musk profile within the API intermediates market to support the synthesis of complex pharmaceutical delivery systems and specialized bioactive compounds. Hexadecenolide has become a focal point for custom synthesis services in the United States, particularly as domestic CDMOs require a 98% fragrance-grade purity to deliver the characteristic musk-mallow scent profile essential for luxury olfactive formulations. Omega-6-hexadecenlactone serves as a vital bulk chemical supplier priority for manufacturers seeking to reduce reliance on volatile sourcing shifts by securing localized, high-specification technical grades that satisfy the rigorous technical specifications of the expanding domestic CDMO growth sector. As an established Ambrettolide supplier in the United States of America, we ensure dependable supply, consistent quality, and complete regulatory documentation, including Ambrettolide CoA and TDS across all grades. Beyond supply, we support partners through the entire product lifecycle from process and formulation development, and analytical method development to scale-up, process optimization, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and nationwide supply chain capabilities and logistics coordination across the United States.
Ambrettolide (CAS No: 28645-51-4) is increasingly utilized by North American flavor and fragrance houses as a high purity fine chemicals building block, valued for its sophisticated macrocyclic musk profile within the API intermediates market to support the synthesis of complex pharmaceutical delivery systems and specialized bioactive compounds. Hexadecenolide has become a focal point for custom synthesis services in the United States, particularly as domestic CDMOs require a 98% fragrance-grade purity to deliver the characteristic musk-mallow scent profile essential for luxury olfactive formulations. Omega-6-hexadecenlactone serves as a vital bulk chemical supplier priority for manufacturer...
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Flavors & Fragrances
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Fragrance Ingredients
Polycyclic Synthetic Musks
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Chemical Properties & Specifications
P261, P273, P280, P302+P352+P333+P313, P362+P364, and P391
Skin Sens. 1B (100%)
Aquatic Acute 1 (100%)
Enhances "radiance" and provides volume to iris, rose, and magnolia accords at trace concentrations (0.1–5%)
Imparts a luxurious, clean scent to shampoos, shower gels, and high-end lotions
Used in premium fabric softeners and detergents for long-lasting, sophisticated freshness
Approved (FEMA 4145) for use in trace amounts to add "mellowing" effects to fruit flavours like blackberry and pear
A staple in luxury scented candles and reed diffusers due to its high burning effectiveness and diffusion.
A powerful macrocyclic musk fixative and fragrance ingredient used to provide a tenacious musk note in fine perfumes and colognes
An aroma component applied in soaps, lotions, and personal care products to enhance scent profile and longevity
A versatile macrocyclic lactone compound used as a reference standard or building block in organic synthesis studies
Under the IFRA 51st Amendment (2023–2026), Ambrettolide has no quantitative restrictions for any category, including Category 4 (Fine Fragrance). This makes it an incredibly safe and flexible tool for perfumers.
Ambrettolide shows "Good" stability in soaps, shampoos, and fabric conditioners (pH 6–10.5). However, its performance is rated as "Poor" in acid cleaners, liquid bleaches, and antiperspirants due to potential degradation in highly acidic or oxidizing environments.
Ambrettolide is a macrocyclic musk compound with the molecular formula C16H28O2, naturally found in angelica sap and ambrette seeds, it is primarily used in the fragrance industry to impart depth, warmth, and fixative properties, while exalting top notes and softening alcohol odors
This compound is universally utilized in the fragrance, perfumery, cosmetics, personal care, household cleaning, and food and beverage industries, as well as under exploration in pharmaceuticals for holistic wellness and aromatherapy
It is commonly used in high-end perfumes, colognes, soaps, detergents, fabric conditioners, and candles, exhibiting solubility in alcohol and insolubility in water
Standard specifications include CAS number 28645-51-4, a molecular weight of 252.4 g/mol, high purity (typically ≥98%), and critical documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Fragrance Ingredients
Sub-Category : Polycyclic Synthetic Musks
Description : Our Ambrettolide is a high-purity, 17-membered macrocyclic lactone that captures the elegant, diffus...
