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2,4,6-Collidine

2,4,6-Collidine

CAS Number: 108-75-8

Molecular Formula: C8H11N

Purity: 99% 2,4,6-Collidine

Hindered Pyridine DerivativesReagents & Bases

About 2,4,6-Collidine

2,4,6-Collidine (CAS 108-75-8) is a vital sterically hindered base in the United States API intermediates market, frequently employed in the total synthesis of complex natural products and specialized pharmaceutical compounds where Pharma/API purity 99% is required to ensure reaction selectivity. sym-Collidine serves a...

2,4,6-Collidine Specifications

CAS Number
108-75-8
Molecular Formula
C8H11N
Molecular Weight
121.18
IUPAC Name
2,4,6-trimethylpyridine
Canonical SMILES
CC1=CC(=NC(=C1)C)C
InChI Key
BWZVCCNYKMEVEX-UHFFFAOYSA-N
InChI
1S/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3
EINECS Number
203-613-3
MDL Number
MFCD00006338
HSN No
29333919
Molecular Weight
121.18
2,4,6-Collidine Assay (GC)
85% (Technical Grade)
Melting Point (Experimental)
-44.5 °C
Boiling Point (Experimental)
170.4°C
Density (Experimental)
0.913 g/cm³ Temp: 20°C
pKa (Experimental)
7.4
Purity
99% 2,4,6-Collidine
Physical appearance
Colorless to yellow clear liquid
odor
Strong, pungent
Melting Point
-43 °C (lit.)
Boiling Point
171-172ºC at 760mmHg
Flash Point
58 °C
Density
0.917 g/mL
Precise Quality
≥98.0%
PSA
12.9 Ų
logP
1.25
Hazard Classes and Categories
Flam. Liq. 3 (99.5%), Acute Tox. 4 (98.9%), Acute Tox. 3 (39.6%), Acute Tox. 4 (44.9%), Skin Irrit. 2 (98.9%), Eye Irrit. 2 (98.9%), Acute Tox. 4 (75.4%), STOT SE 3 (84%)
Precautionary Statement Codes
P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 Acute Tox. 4 (100%)

Peptide Synthesis & Coupling

In solid-phase and liquid-phase peptide synthesis, Preferred base for minimising racemisation during the activation of amino acids. Controlled basicity ensures efficient coupling without compromising the chiral integrity of the peptide chain

Sterospecific Silylation (Alcohol Protection)

"Gold Standard" for the preparation of silyl ethers (like TBS, TMS, or TIPS ethers). In the synthesis of complex natural products and APIs, it scavenges protons effectively while its steric bulk prevents it from attacking the sensitive silylating agent itself

Nucleoside & Oligonucleotide Chemistry

Phosphoramidite method for DNA/RNA synthesis. Acid scavenger during the deprotection and oxidation steps, where milder bases like Pyridine might lead to lower yields or side reactions

Dehydrohalogenation Reactions

Highly effective in the elimination of hydrogen halides to form alkenes. Hindered nature promotes the E2 elimination mechanism while preventing competing nucleophilic substitution (SN2) that would occur with less-bulky amines

Total Synthesis of Macrolides & Polyketides

Universally used in the construction of large-ring lactones, where regioselective control of functional groups is essential

Analytical Chemistry & Microscopy

Historically utilized as a buffering agent and a specialized "clearing agent" in tissue processing and electron microscopy due to its unique refractive index and chemical stability

Organic Synthesis

A sterically hindered base used in organic synthesis, such as in dehydrohalogenation reactions and the cleavage of certain protecting groups

Chemical Analysis

A specialized reagent or solvent in analytical chemistry and spectroscopy due to its unique chemical properties

Chemical Intermediate

A building block or precursor in the production of agricultural chemicals, rubber chemicals, and specialized dyes

Pharmaceutical Research

A chemical reagent utilized in the synthesis and modification of bioactive molecules and drug discovery processes

2,4,6-Collidine FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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