2-hydroxy-6-(trifluoromethyl)pyridine

2-hydroxy-6-(trifluoromethyl)pyridine

CAS Number
34486-06-1
Molecular Formula
C6H4F3NO
Acute ToxicAcute Toxic
IrritantIrritant
CDMO Capabilities: Catalytic Ring Cyclisation → Trifluoromethylation → Crystallisation & Isolation | Specialty Chemical Route

About 2-hydroxy-6-(trifluoromethyl)pyridine

2-Hydroxy-6-(trifluoromethyl)pyridine (6-(Trifluoromethyl)pyridin-2-ol), CAS 34486-06-1, is a fluorinated heterocyclic intermediate and agrochemical building block - white to off-white crystalline powder, also known as 6-(Trifluoromethyl)-2-pyridinol or 6-(trifluoromethyl)pyridin-2(1H)-one, used by manufacturers of Api...

Synonyms

  • C6H4F3NO
  • Picoxystrobin metabolite
  • ACMC-209i7u
  • XXRUAAOADAPPII-UHFFFAOYSA-N
  • 6-Trifluoromethylpyridin-2-ol
View all

2-hydroxy-6-(trifluoromethyl)pyridine Specifications

CAS Number
34486-06-1
Molecular Formula
C6H4F3NO
Molecular Weight
163.10 g/mol
IUPAC Name
6-(trifluoromethyl)-1H-pyridin-2-one
Canonical SMILES
C1=CC(=O)NC(=C1)C(F)(F)F
InChI Key
XXRUAAOADAPPII-UHFFFAOYSA-N
InChI
InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-5(11)10-4/h1-3H,(H,10,11)
UNII Code
81T56GP86W
DSSTox Substance ID
DTXSID80436222
EINECS Number
803-542-3
MDL Number
MFCD08061317
Molecular Weight
163.10 g/mol
XLogP3
1.1
Hydrogen Bond Acceptor Count
4
Monoisotopic Mass
163.02449824 Da
GHS Hazard Statements
H301 (97.4%): Toxic if swallowed H319 (100%): Causes serious eye irritation
Hazard Classes and Categories
Acute Tox. 3 (97.4%) Eye Irrit. 2A (100%)

Agrochemical Active Ingredient Synthesis

A primary fluorinated intermediate for synthesising high-potency selective herbicides, fungicides, and insecticides with enhanced environmental stability

Pharmaceutical API Building Block

A versatile pyridine synthon is utilised in drug discovery to construct metabolically resistant heterocycles bearing lipophilic -CF₃ substituents

Chlorination & 2-Chloro-6-(trifluoromethyl)pyridine Production

A functional starting material was converted smoothly via phosphorus oxychloride (POCl₃) into 2-chloro-6-(trifluoromethyl)pyridine for cross-coupling reactions

Speciality Etherification & Nucleophilic Coupling

A reactive pyridinol undergoing O-alkylation and palladium-catalysed coupling to build complex fluorinated biaryl systems

CDMO Custom Fine Chemical Manufacturing

A standardised raw material processed by custom development platforms for commercial-scale fluorinated intermediate production

  1. C6H4F3NO
  2. Picoxystrobin metabolite
  3. ACMC-209i7u
  4. XXRUAAOADAPPII-UHFFFAOYSA-N
  5. 6-Trifluoromethylpyridin-2-ol

2-hydroxy-6-(trifluoromethyl)pyridine FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

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TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

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California Prop 65*

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