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4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (EMCA)

4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (EMCA)

CAS Number: 127892-62-0

Molecular Formula: C7H9ClN2O2

Purity: 99.34

Aromatic Carboxylic Acids & DerivativesHalogenated IntermediatesCustom Synthesis Substituted PyrazolesIntermediate Tolfenpyrad SynthesisPyrazole Building Block Crop ProtectionMitochondrial Complex I Inhibitor PrecursorChlorinated Pyrazole Agrochemical R&D

About 4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (EMCA)

4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid is a key precursor used across domestic chemical manufacturing facilities to synthesize next-generation crop protection actives, insecticides, and specialized heterocyclic molecules. We supply commercial and technical-grade EMCA (CAS No: 1192591-65-3) to sustain m...

Synonyms

  • C7H9ClN2O2
  • Tebufenpyrad metabolite
  • ACMC-1BXK0
  • NXAIFVHVBHMNJS-UHFFFAOYSA-N
  • CTK0H4311
View all

4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (EMCA) Specifications

CAS Number
127892-62-0
Molecular Formula
C7H9ClN2O2
Molecular Weight
188.61
IUPAC Name
4-chloro-3-ethyl-1-methylpyrazole-5-carboxylic acid
Canonical SMILES
CCC1=NN(C(=C1Cl)C(=O)O)C
InChI Key
NXAIFVHVBHMNJS-UHFFFAOYSA-N
InChI
1S/C7H9ClN2O2/c1-3-4-5(8)6(7(11)12)10(2)9-4/h3H2,1-2H3,(H,11,12)
PubChem CID
14770682
EINECS Number
836-047-6
MDL Number
MFCD08459057
HSN No
29331990
Molecular Weight
188.61
Melting Point (Experimental)
133-136 °C
Boiling Point (Predicted)
339.522±42.00°C Press: 760.00 Torr
Density (Predicted)
1.404±0.14 g/cm3 Temp: 25°C; Press: 760 Torr
pKa (Predicted)
1.899±0.38 Most Acidic Temp: 25 °C
Purity By HPLC
99.34
Hazard Classes and Categories
Skin Irrit. 2 (100%), Eye Irrit. 2 (100%), STOT SE 3 (50%)
Precautionary Statement Codes
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Synthesis of Tolfenpyrad

Production of Tolfenpyrad. Acid intermediate is reacted with 4-(4-methylphenoxy)benzylamine (TOBA) to form the final amide bond. Tolfenpyrad is highly effective against a broad spectrum of pests, including thrips, aphids, and mites in vegetables, fruits, and teacrops

Heterocyclic Building Blocks

Substituted pyrazoles are privileged scaffolds in medicinal chemistry. Specific carboxylic acid is used in drug discovery to explore COX-2 inhibitors and other enzyme-targeting therapies where a chloro-pyrazole moiety is needed for optimized binding affinity

Regioselective Reagents

Reagent in the creation of complex nitrogen-containing molecules where the 4-chloro substitution acts as a site for further functionalization via cross-coupling reactions

COA
Download
  1. C7H9ClN2O2
  2. Tebufenpyrad metabolite
  3. ACMC-1BXK0
  4. NXAIFVHVBHMNJS-UHFFFAOYSA-N
  5. CTK0H4311

4-Chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (EMCA) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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