1-Hydroxybenzotriazole

1-Hydroxybenzotriazole

CAS Number
2592-95-2
Molecular Formula
C6H5N3O
Purity
1-Hydroxybenzotriazole 97% purity

About 1-Hydroxybenzotriazole

1-Hydroxybenzotriazole (CAS 2592-95-2) serves as a critical peptide coupling reagent and racemization suppressant in the United States, where Pharma/API purity 99% is essential for domestic CDMOs specializing in high-complexity therapeutic synthesis. HOBt anhydrous is witnessing increased demand across North American c...

Variants

1-Hydroxybenzotriazole Anhydrous

CAS: 2592-95-2

Synonyms

  • 1-hydroxybenzotriazole
  • 1-hydroxybenzotriazole, ammonium salt
  • 1-hydroxybenzotriazole, sodium salt
  • HOBt
  • N-hydroxybenzotriazole
View all

1-Hydroxybenzotriazole Specifications

CAS Number
2592-95-2
Molecular Formula
C6H5N3O
Molecular Weight
135.12 g/mol (anhydrous basis)
IUPAC Name
1-hydroxybenzotriazole
Canonical SMILES
C1=CC=C2C(=C1)N=NN2O
InChI Key
ASOKPJOREAFHNY-UHFFFAOYSA-N
InChI
InChI=1S/C6H5N3O/c10-9-6-4-2-1-3-5(6)7-8-9/h1-4,10H
HSN No
29339900
solubility
8.4 [ug/mL] (The mean of the results at pH 7.4)
Molecular Weight
135.12 g/mol (anhydrous basis)
Purity
1-Hydroxybenzotriazole 97% purity

Peptide Coupling Reagent

A widely used additive in peptide synthesis and amide bond formation that suppresses racemization and enhances coupling efficiency by converting O-acylisourea intermediates into more stable active esters

Organic Synthesis Building Block

A versatile nucleophilic catalyst and stoichiometric additive used to accelerate nucleophilic acyl substitution reactions, particularly in the synthesis of pharmaceuticals, oligonucleotides, and complex organic molecules

Corrosion Inhibitor

A functional additive employed in coatings, paints, and metalworking fluids to protect metal surfaces from oxidation and enhance the durability of materials in automotive and construction applications

Polymer Stabilizer

A specialized additive used in the production of polymers and plastics to improve thermal stability and provide UV resistance, preventing photodegradation in outdoor environments.

  1. 1-hydroxybenzotriazole
  2. 1-hydroxybenzotriazole, ammonium salt
  3. 1-hydroxybenzotriazole, sodium salt
  4. HOBt
  5. N-hydroxybenzotriazole

1-Hydroxybenzotriazole FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

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