Polysorbate 80

Polysorbate 80

CAS Number
9005-65-6
Molecular Formula
(C64H124O26)n-multiple grades
Purity
101.2
E-Number E-433Fatty Acid: Oleic AcidHLB Value: 15.0Nonionic SurfactantsUSP, EP, Food grades

About Polysorbate 80

Polysorbate 80 is a nonionic surfactant and emulsifier widely used in pharmaceuticals, food production, and cosmetics. (Alkest TW 80) stabilizes emulsions, enhances solubility of active ingredients, and reduces surface tension in aqueous solutions. Polysorbate 80 is a hydrophilic nonionic surfactant widely used in the ...

Polysorbate 80 Specifications

CAS Number
9005-65-6
Molecular Formula
(C64H124O26)n-multiple grades
IUPAC NameORBotanical Name
Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs. (9CI, ACI)
InChI Key
RGPBUVUVZKQNHD-MDZDMXLPSA-N
EINECS Number
34-18-05-90
FEMA Number
2917
MDL Number
MFCD00152531
UNSPSC Code
12161700
HSN No
34024200
Appearance
Yellow to Amber Oily Liquid
Colour in Gardner
3.7
PH 5% solution
6.58
Moisture %
1.86
Saponification Value
47
Hydroxly Value
75
Assay/ Polysorbate 80 purity
101.2

Pharmaceuticals: Solubilizing APIs

Formulation of vaccines and injectable drugs to keep proteins and active ingredients in solution. Prevent the adsorption of drugs to the surfaces of glass or plastic containers

Food & Nutrition: Texture & Stability

Provides a creamy texture in frozen desserts and to prevent "bloom" in chocolates. Polysorbate 60 is specifically favored in bakery products for dough strengthening, while Polysorbate 80 is the standard for milk and cream substitutes

Beauty & Personal Care: Clarity & Wash-off

Solubilizers to incorporate essential oils and fragrances into water-based products like body washes and toners without clouding. Facilitates the easy rinse-off of oil-based cleansers.

End use-Drug Delivery

Enhances bioavailability by improving solubility of hydrophobic drugs.

End use-Emulsion Stabilizer

Prevents phase separation in both food and pharmaceutical emulsions.

End use-Vaccine Production

Stabilizes biological molecules in vaccines (e.g., COVID-19, flu).

Metabolism

Polysorbates undergo degradation by auto-oxidation, producing reactive peroxides, in addition to hydrolysis. Exposure to light of polysorbate 80 aqueous solution leads autoxidation of the alkyl polyoxyethylene chain leading to the production of hydroperoxide derivatives. The peroxides cause oxidative damage to the protein molecule that makes up the formulation. The residual peroxides and the rate of peroxide generation as a result of light exposure are found to vary for polysorbate 80 of different grades/from different sources.

Temperature

Store at room temperature (15–30°C or 59–86°F)

Packaging Options

25 kg drums, 200 kg barrels, customized packaging for pharma & food applications

Polysorbate 80 FAQs

Minimum Order Quantity

25 kg (pilot) · 1 MT (commercial)

Lead Time

3 – 5 weeks ex-works

Incoterms

FOB · CIF

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

Regional Availability

India · EU · Middle East · Southeast Asia

Documentation

SDS · COA · TDS available on request

Compliance & Quality

REACH registered*

GHS/SDS available

ISO 9001:2015 site*

RoHS compliant*

Global sourcing network

Consistent quality & reliability

End-to-end technical support

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