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Zofran (Ondansetron hydrochloride dihydrate)

Zofran (Ondansetron hydrochloride dihydrate)

CAS Number: 103639-04-9

Molecular Formula: C18H24ClN3O3

Therapeutic category: Antiemetic AgentsSerotonin 5-HT3 Receptor AntagonistGrade: USPREACH RegisteredISO 9001 Plant API

About Zofran (Ondansetron hydrochloride dihydrate)

Ondansetron Hydrochloride Dihydrate (Zensana) is a selective serotonin 5-HT3 receptor antagonist used as an antiemetic for preventing nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative conditions. It works by blocking serotonin receptors in the central nervous system and gastrointestinal ...

Zofran (Ondansetron hydrochloride dihydrate) Specifications

CAS Number
103639-04-9
Molecular Formula
C18H24ClN3O3
Molecular Weight
365.9 g/mol
IUPAC Name
9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;dihydrate;hydrochloride
Canonical SMILES
CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.O.O.Cl
InChI Key
VRSLTNZJOUZKLX-UHFFFAOYSA-N
InChI
1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2
PubChem CID
59774
EINECS Number
600-465-5
MDL Number
MFCD00374371
UNSPSC Code
51101901
HSN No
2933.29.90
Molecular Weight
365.9 g/mol
Heavy atom count
25
Topological Polar Surface Area
41.8 Ų
Melting Point
180–182°C (decomposes)
LogP (Partition Coefficient)
2.1
GHS Hazard Statements
H301 (100%), H318 (84.6%), H319 (11.1%), H400 (84.6%) H410 (82.9%)
Precautionary Statement Codes
P264, P264+P265, P270, P273, P280, P301+P316, P305+P351+P338, P305+P354+P338, P317, P321, P330, P337+P317, P391, P405, and P501

Pharmaceutical Use

Prevention and treatment of nausea and vomiting in (Cancer chemotherapy), radiotherapy (Radiation therapy), and treat postoperative surgery (Postoperative care)

Mechanism of Action

Selective 5-HT3 receptor antagonism reduces central and peripheral nausea signaling

Oral and Injectable Formulations

Supports tablets, oral disintegrating tablets, and injectable dosage forms

Metabolic Stability

Resistant to rapid metabolism, providing consistent therapeutic effects

R & D

Preferred in pharmacokinetic studies, 5-HT3 receptor studies, and preclinical antiemetic research

B2B Features

Suitable for API supply to pharmaceutical manufacturers, contract formulation & clinical research

Temperature

Store at 15–25°C (59–77°F)

Environment & Protection

Protect from moisture and light; keep in tightly sealed containers

Zofran (Ondansetron hydrochloride dihydrate) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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