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Venlafaxine Hydrochloride

Venlafaxine Hydrochloride

CAS Number: 99300-78-4

Molecular Formula: C17H28ClNO2

USP, BP, EP monographs CompliantTherapeutic Category: AntidepressantSNRIGrade: IP/USPSecond-Generation SNRISecond-Generation SNRIDual-Action AntidepressantRacemic API for CNS ApplicationsISO Certified Venlafaxine Plant

About Venlafaxine Hydrochloride

Venlafaxine Hydrochloride is a synthetic antidepressant belonging to the serotonin-norepinephrine reuptake inhibitor (SNRI) class. Also known as VENLAFAXINE HCl by manufacturers and fundamentally used to treat major depressive disorder, generalized anxiety disorder and panic disorder. Venlafaxine is a racemic mixture o...

Venlafaxine Hydrochloride Specifications

CAS Number
99300-78-4
Molecular Formula
C17H28ClNO2
IUPAC Name
1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride
Canonical SMILES
CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
InChI Key
QYRYFNHXARDNFZ-UHFFFAOYSA-N
InChI
1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
Appearance
White to off-white crystalline solid
Solubility in Water
572 mg/mL (adjusted to ionic strength of 0.2 M with sodium chloride) Partition Coefficient (Log P) 0.43 (octanol:water, 0.2 M sodium chloride)
Melting Point
215–216°C
Boiling Point
Not applicable (decomposes)
pKa
9.4 at 23°C
Hazard Classification
Eye Irritation Category 2A; Acute Toxicity Oral Category 4
Signal Word
Warning
(H) Statements
H302: Harmful if swallowed. H319: Causes serious eye irritation.
(P) Statements
P264: Wash hands thoroughly after handling. P270: Do not eat, drink, or smoke when using this product. P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P501: Dispose of contents/container in accordance with local regulations.

Treatment of (MDD)

Used as a frontline antidepressant in the management of Major Depressive Disorder by enhancing the availability of serotonin and norepinephrine in the central nervous system.

Management of (GAD)

Helps reduce excessive worry and tension associated with Generalized Anxiety Disorder, offering long-term relief with minimal sedative effects.

Relief from (SAD)

Prescribed for individuals with persistent social fear or avoidance, improving social interaction and quality of life.

Control of Panic Disorder

Reduces the frequency and intensity of panic attacks by regulating neurotransmitter activity in the brain.

Formulation in Oral Extended-Release Products

Commonly formulated in extended-release tablets or capsules for once-daily dosing, improving patient compliance.

Pharmacokinetics

High oral bioavailability with extensive hepatic metabolism to active metabolite ODV.

Protein Binding

Approximately 27% for parent compound; 30% for ODV .

Elimination Half-Life

5±2 hours for immediate-release; 15±6 hours for extended-release formulations.

Excretion

Predominantly renal, with 87% excreted in urine (5% unchanged drug; 29% as ODV; 53% as other metabolites) .

Storage Conditions

Store at controlled room temperature, 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F to 86°F). Packaging: Available in various quantities suitable for pharmaceutical manufacturing needs.

Packaging

Available in various quantities suitable for pharmaceutical manufacturing needs.

Venlafaxine Hydrochloride FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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