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Tromethamine

Tromethamine

CAS Number: 77-86-1

Molecular Formula: C4H11NO3

About Tromethamine

Trometamol (CAS 77-86-1) is extensively used across North American pharmaceutical and biotechnology sectors as an essential biological buffering agent and alkalizer, critical for stabilizing injectables and mitigating metabolic acidosis in critical care therapeutics. Tris(hydroxymethyl)aminomethane has increasingly bec...

Synonyms

  • Tri(hydroxymethyl)aminomethane
  • Tris Buffer
  • Tris(hydroxymethyl)aminomethane
  • Tris-Magnesium(II)-Potassium Chloride Buffer
  • Tris-Mg(II)-KCl Buffer
View all

Tromethamine Specifications

CAS Number
77-86-1
Molecular Formula
C4H11NO3
IUPAC Name
2-amino-2-(hydroxymethyl)propane-1,3-diol
Canonical SMILES
C(C(CO)(CO)N)O
InChI Key
LENZDBCJOHFCAS-UHFFFAOYSA-N
InChI
InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
HSN No
29221990
melting_point
171-172 °C
boiling_point
219-220 °C at 10 mm Hg
solubility
79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride
Precautionary Statement Codes
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
Skin Irrit. 2 (81.4%) Skin Sens. 1 (82.9%)

Pharmaceuticals

An active buffering agent and counterion used to manage metabolic acidosis and formulate pharmaceutical drugs

Cosmetics Industry

A pH regulator, emulsifier, and stabilizer used in skincare and personal care products to reduce irritation

Biotechnology and Research

An effective buffering component used in biological experiments, molecular biology, and PCR testing

Industrial Applications

A versatile dispersant and additive used in coatings, cleaning solutions, and rubber processing

  1. Tri(hydroxymethyl)aminomethane
  2. Tris Buffer
  3. Tris(hydroxymethyl)aminomethane
  4. Tris-Magnesium(II)-Potassium Chloride Buffer
  5. Tris-Mg(II)-KCl Buffer

Tromethamine FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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