Trimethylchlorosilane

CAS Number: 75-77-4

Molecular Formula: C3H9ClSi

Purity: Trimethylchlorosilane 99% purity

About Trimethylchlorosilane

Trimethylchlorosilane (CAS 75-77-4) is an indispensable silylating agent in the United States pharmaceutical sector, where high purity fine chemicals are mandated for the protection of alcohols and amines during the complex synthesis of antibiotics and steroids. Chlorotrimethylsilane has become a focal point for North ...

Synonyms

chlorotrimethylsilane
trimethylchlorosilane
Chlorotrimethylsilane
75-77-4
TRIMETHYLCHLOROSILANE

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Trimethylchlorosilane Specifications

CAS Number

75-77-4

Molecular Formula

C3H9ClSi

Molecular Weight

108.64 g/mol

IUPAC Name

chloro(trimethyl)silane

Canonical SMILES

C[Si](C)(C)Cl

InChI Key

IJOOHPMOJXWVHK-UHFFFAOYSA-N

InChI

InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

PubChem CID

6397

HSN No

29319090

CAS Number

75-77-4

Molecular Formula

C3H9ClSi

Molecular Weight

108.64 g/mol

IUPAC Name

chloro(trimethyl)silane

Canonical SMILES

C[Si](C)(C)Cl

InChI Key

IJOOHPMOJXWVHK-UHFFFAOYSA-N

InChI

InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

PubChem CID

6397

HSN No

29319090

melting_point

-72 °F (EPA, 1998)

boiling_point

135 °F at 760 mmHg (EPA, 1998)

solubility

Decomposes (NTP, 1992)

density

0.854 at 77 °F (EPA, 1998) - Less dense than water; will float

Molecular Weight

108.64 g/mol

Purity

Trimethylchlorosilane 99% purity

Silylating Agent

A versatile organosilicon reagent primarily used in organic synthesis for the protection of functional groups such as alcohols, amines, and carboxylic acids by forming stable trimethylsilyl (TMS) ethers and amines

Silicone Precursor

A fundamental building block and intermediate in the chemical industry used to manufacture various silicone products, including lubricants, sealants, oils, resins, and hexamethyldisiloxane (HMDSO)

Derivatization Reagent

An essential analytical reagent employed in gas chromatography (GC) to increase the volatility and thermal stability of polar or non-volatile compounds like glucose and amino acids

Surface Modification Agent

A functional silane coupling agent used to create hydrophobic or lipophilic coatings on inorganic surfaces such as glass, metal, and silica to enhance adhesion and water resistance

Pharmaceutical Intermediate

A critical reagent used in the synthesis of active pharmaceutical ingredients (APIs) and antibiotics, including the preparation of 7-aminocephalosporanic acid (7-ACA) for cephalosporin production.