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Trans-4-Aminocyclohexanol (4-TAC) is a bicyclic amino alcohol used in synthesizing chiral intermediates for APIs in pharmaceutical industry. For targeting neuroactive agents and selective ligands, the 4-TAC intermediate is currently in drug discovery programs . The trans configuration of 4-TAC gives stereochemical stability for enantioselective synthesis essentials. 4-TAC currently evaluated cyclohexanol for its potential in targeting central nervous system (CNS), analgesic, and anti-inflammatory pathways.
Trans-4-Aminocyclohexanol (4-TAC) is a bicyclic amino alcohol used in synthesizing chiral intermediates for APIs in pharmaceutical industry. For targeting neuroactive agents and selective ligands, the 4-TAC intermediate is currently in drug discovery programs . The trans configuration of 4-TAC gives stereochemical stability for enantioselective synthesis essentials. 4-TAC currently evaluated cyclohexanol for its potential in targeting central nervous system (CNS), analgesic, and anti-inflammatory pathways.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Eye Irritation: Category 2A Skin Irritation: Category 2 Acute Toxicity (Oral): Category 4
H302: Harmful if swallowed H319: Causes serious eye irritation H315: Causes skin irritation
P280: Wear protective gloves and eye protection P305+P351+P338: IF IN EYES: Rinse cautiously with water P261: Avoid breathing dust/fume P264: Wash hands thoroughly after handling
Used in the synthesis of chiral drug molecules, particularly CNS modulators
Scaffold in the design of selective ligands or inhibitors
Utilized in stereoselective synthesis studies
*Readily available for functionalization and derivatization *Suitable for formulation into custom drug discovery programs
Precursor in the development of neuropharmaceuticals, pain modulators, and specialized CNS drugs
15–30°C
25 kg fiber drums / HDPE jars
2 drums high
2 years in sealed condition
Non-hazardous, standard containerized transport
Assay ≥98%, validated by HPLC methods.
Yes, often used in regulatory filing pathways as an intermediate.
Enantiomerically pure variants can be offered upon request.
Yes, COA, MSDS, and export documents are provided. REACH status available.
Dispatch in 7–10 days. MOQ typically starts from 1 kg for R&D.
As a stable scaffold in asymmetric synthesis or CNS-focused lead molecules.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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