Tetrabutylammonium Fluoride Trihydrate (TBAF) (CAS NO : 87749-50-6)

Tetrabutylammonium Fluoride Trihydrate (CAS No: 87749-50-6) serves as a premier, versatile reagent in sophisticated organic synthesis, primarily valued by American laboratories for its exceptional solubility in polar organic solvents and its role as a highly efficient source of nucleophilic fluoride ions for the critical deprotection of silyl ethers. The reagent's utility extends significantly into the domestic pharmaceutical and semiconductor industries, where its mild basicity and non-nucleophilic properties facilitate complex transformations such as aldol-type condensations, Michael additions, and Hiyama cross-coupling reactions without requiring the harsh, anhydrous conditions typically associated with traditional strong bases. With the global market projected to reach $6.12 billion by 2025, driven by a 16.49% CAGR, high-purity 98% and 99% grades are increasingly essential for sensitive U.S. applications in novel drug development and advanced electronic cleaning processes, particularly as CDMOs and specialty chemical manufacturers scale up production capabilities. As a globally established Tetrabutylammonium Fluoride Trihydrate (TBAF) supplier with a consistent purity of 99%, we ensure dependable supply, consistent quality, and complete regulatory documentation, including TBAF CoA and TDS across all grades for the American market. Beyond supply, we support partners through the entire product lifecycle from route scouting, process and formulation development, and analytical method development to scale-up, process optimization, and pilot-to-commercial manufacturing. Our teams also assist with GMP-compliant quality assurance, regulatory documentation, and global supply chain and logistics coordination.