TENOFOVIR DISOPROX

CAS Number: 202138-50-9

Molecular Formula: C19H30N5O10P·C4H4O4

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About TENOFOVIR DISOPROX

Tenofovir Disoproxil (CAS 201306-15-2) is a cornerstone in the US API intermediates market, primarily utilized for the synthesis of tenofovir disoproxil fumarate, where a Pharma/API purity of 99% is vital to ensure compliance with stringent FDA and American Chemical Society standards. Bis(POC)PMPA has seen a significan...

TENOFOVIR DISOPROX Specifications

CAS Number

202138-50-9

Molecular Formula

C19H30N5O10P·C4H4O4

Molecular Weight

635.51 g/mol

IUPAC Name

[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate

Canonical SMILES

C[C@H](CN1C=NC2=C\(N=CN=C21\)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C

InChI Key

JFVZFKDSXNQEJW-CQSZACIVSA-N

InChI

InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1

EINECS Number

606-442-6

MDL Number

MFCD00952920

HSN No

30049099

CAS Number

202138-50-9

Molecular Formula

C19H30N5O10P·C4H4O4

Molecular Weight

635.51 g/mol

IUPAC Name

[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate

Canonical SMILES

C[C@H](CN1C=NC2=C\(N=CN=C21\)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C

InChI Key

JFVZFKDSXNQEJW-CQSZACIVSA-N

InChI

InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1

EINECS Number

606-442-6

MDL Number

MFCD00952920

HSN No

30049099

Molecular Weight

635.51 g/mol

Melting Point

113-115°C

Boiling Point

642.7±65.0 °C at 760 mmHg

Freezing point

113-115°C

Density

1.45 g/cm3

pKa

3.75

PSA

189 Å²

logP

1.25

Average mass

635.52 g/mol

Monoisotopic mass

635.18398777 Da

Molar mass

519.4 g/mol

Vapour pressure

2.06E-16mmHg at 25°C

Precautionary Statement Codes

P264, P270, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P405, and P501

Hazard Classes and Categories

Acute Tox. 4 (100%) Skin Irrit. 2 (100%)

HIV-1 Treatment

Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor (NRTI) used in combination with other antiretroviral agents to manage HIV-1 infection in adults and pediatric patients at least 2 years of age

Chronic Hepatitis B Treatment

The medication is indicated for the treatment of chronic hepatitis B virus (HBV) infection in both adults and pediatric patients, working by inhibiting the viral DNA polymerase enzyme to reduce viral load

HIV Prevention (PrEP)

When used in fixed-dose combinations with emtricitabine, it is utilized for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection in high-risk individuals

Pharmaceutical Development

Served as a critical advancement in antiretroviral therapy as a prodrug of tenofovir, designed to improve oral bioavailability and membrane permeability for more effective intracellular delivery.