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Pivaloyl Chloride

Pivaloyl Chloride

CAS Number: 3282-30-2

Molecular Formula: C5H9ClO

Synthesis pivaloyloxymethyl estersTrimethylacetyl chloride 99%Top note fruity-floral compositionPivalic acid (Pivalates) derivedNote: Bergamot, Rose, Pear, Lily of the ValleyAroma Compound IntermediateAroma Ester Precursor

About Pivaloyl Chloride

Pivaloyl Chloride, also known as Trimethylacetyl Chloride and 2,2-Dimethylpropanoyl Chloride (CAS No. 3282-30-2), is a high-purity acyl chloride intermediate widely used in pharmaceutical, agrochemical, and specialty chemical synthesis across the United States. It serves as a critical acylating reagent in the productio...

Synonyms

  • pivaloyl chloride
  • Pivaloyl chloride
  • 3282-30-2
  • Trimethylacetyl chloride
  • 2,2-DIMETHYLPROPANOYL CHLORIDE
View all

Pivaloyl Chloride Specifications

CAS Number
3282-30-2
Molecular Formula
C5H9ClO
Molecular Weight
120.58
IUPAC Name
2,2-dimethylpropanoyl chloride
Canonical SMILES
CC(C)(C)C(=O)Cl
InChI Key
JVSFQJZRHXAUGT-UHFFFAOYSA-N
InChI
1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
EINECS Number
221-921-6
MDL Number
MFCD00000709
Molecular Weight
120.58
Boiling Point (Experimental)
102-104 °C
Density (Experimental)
0.9798 g/cm₴ Temp: 20°C
pKa (Experimental)
5.03
Hazard Classes and Categories
Flam. Liq. 2 (81.8%), Met. Corr. 1 (58.6%), Acute Tox. 4 (81.8%), Skin Corr. 1B (82.2%), Eye Dam. 1 (59.9%), Acute Tox. 2 (75.7%)
Precautionary Statement Codes
P210, P233, P234, P240, P241, P242, P243, P260, P264, P264+P265, P270, P271, P280, P284, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P330, P363, P370+P378, P390, P403+P233, P403+P235, P405, P406, and P501
Physical Hazards
Flammable Liquid (Cat 2); Corrosive to Metals (Cat 1).

Pharmaceutical Industry

Pivaloyl Chloride is a vital reagent in the US pharmaceutical industry. Primarily used as a selective protecting group in complex organic synthesis. It is essential for producing prodrugs, such as pivaloyloxymethyl (POM) esters, which significantly enhance the oral absorption and effectiveness of antibiotics like Ampicillin and various antiviral medications.

Agrochemicals

In the agrochemical sector, this compound serves as a key building block for high-efficiency herbicides and insecticides. It is used to synthesize active ingredients that require specific metabolic stability to remain effective in diverse environmental conditions. By utilizing Pivaloyl Chloride, manufacturers can produce advanced crop protection products that meet stringent US performance and environmental safety standards.

Specialty Chemicals & Polymers

A major industrial application for Pivaloyl Chloride is the production of organic peroxide initiators, such as tert-butyl peroxypivalate. These initiators are critical for the polymerization of vinyl monomers, supporting the large-scale manufacturing of essential plastics like Polyvinyl Chloride (PVC) and Low-Density Polyethylene (LDPE). These materials are foundational to the US industrial supply chain, from construction to packaging.

Fine Chemicals & Research

For medicinal chemistry and research organizations, Pivaloyl Chloride is a preferred reagent for selective acylation. Its bulky chemical profile provides high predictability and control during chemical reactions, making it an invaluable tool for lead optimization and the development of new chemical entities (NCEs). It supports the US biotech and research ecosystem in accelerating the transition from lab-scale discovery to pilot production.

Atmospheric Shielding

Storage under a Dry Nitrogen or Argon Blanket is mandatory to prevent hydrolysis

Temperature Requirements

Store in a cool, dry, fireproof area (+2°C' to +30°C)

Containment

Original glass-lined or high-density fluorinated polyethylene (HDPE) containers. Avoid metal containers due to HCI corrosion risk

Incompatibilities

Keep strictly away from water, alcohols, strong bases, amines, and oxidizing agents

  1. pivaloyl chloride
  2. Pivaloyl chloride
  3. 3282-30-2
  4. Trimethylacetyl chloride
  5. 2,2-DIMETHYLPROPANOYL CHLORIDE

Pivaloyl Chloride FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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