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Phenobarbital (CAS NO : 50-06-6)

Phenobarbitone (Phenobarbital) is a long-acting barbiturate pharmaceutical essential medicine with anticonvulsant, hypnotic, and sedative properties. It has been preferred to be used in the treatment of epilepsy and as a pre-anesthetic agent. The sodium salt version improves water solubility, making it suitable for parenteral administration. Phenobarbitone, also known as Phenobarbitol, is also available in two pharmacologically equivalent forms: Phenobarbitone (Base) - Preferred in oral solid dosage formulations and Phenobarbitone Sodium - A highly water-soluble salt used in injectables and oral solutions. Also both forms are included in BP/EP/USP pharmacopeias & retain identical CNS depressant activity. Phenobarbitone Sodium manufacturers formulate it in injectable and oral dosage forms such as tablets, syrups, or solutions, fundamentally used for managing seizure disorders in human and veterinary contexts.

Phenobarbitone (Phenobarbital) is a long-acting barbiturate pharmaceutical essential medicine with anticonvulsant, hypnotic, and sedative properties. It has been preferred to be used in the treatment of epilepsy and as a pre-anesthetic agent. The sodium salt version improves water solubility, making it suitable for parenteral administration. Phenobarbitone, also known as Phenobarbitol, is also available in two pharmacologically equivalent forms: Phenobarbitone (Base) - Preferred in oral solid dosage formulations and Phenobarbitone Sodium - A highly water-soluble salt used in injectables and oral solutions. Also both forms are included in BP/EP/USP pharmacopeias & retain identical CNS depress...

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Pharmaceutical

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Pharmaceutical Actives & Precursors

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Active Pharmaceutical Ingredients (APIs)

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Chemical Properties & Specifications

Applications of Phenobarbital

Antiepileptic Therapy

Used in the treatment and management of all types of seizures, especially generalized tonic-clonic and partial seizures.

Sedative & Hypnotic Use

Previously employed as a sedative-hypnotic for short-term insomnia and anxiety-related conditions.

Veterinary Use

Also used as an antiepileptic and anesthetic adjunct in veterinary medicine.

Variations

– Base form is utilized in tablets and capsules. – Sodium salt is used in injectable and rapid-onset oral solutions.

Medical Significance

Used as a first-line antiepileptic agent in both human and veterinary medicine. Long-acting action, affordability make it especially valuable in resource-limited medical settings.

Additional Features

-High Potency: Effective at low therapeutic doses. -Long Half-Life: Suitable for once-daily administration in epilepsy management. -Cost-Effective: One of the oldest and most affordable anticonvulsants globally.

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