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Phenobarbital

Phenobarbital

CAS Number: 50-06-6

Molecular Formula: C12H12N2O3

Therapeutic Category: CNS AgentBP/EP/USP GradesUNII 4R03HRY3US

About Phenobarbital

Phenobarbitone (Phenobarbital) is a long-acting barbiturate pharmaceutical essential medicine with anticonvulsant, hypnotic, and sedative properties. It has been preferred to be used in the treatment of epilepsy and as a pre-anesthetic agent. The sodium salt version improves water solubility, making it suitable for par...

Synonyms

  • Acid, Phenylethylbarbituric
  • Gardenal
  • Hysteps
  • Luminal
  • Monosodium Salt Phenobarbital
View all

Phenobarbital Specifications

CAS Number
50-06-6
Molecular Formula
C12H12N2O3
Molecular Weight
254.22 g/mol
IUPAC Name
5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
Canonical SMILES
CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
InChI Key
DDBREPKUVSBGFI-UHFFFAOYSA-N
UNII Code
UNII 4R03HRY3US
EINECS Number
200-007-0
MDL Number
MFCD00066494
UNSPSC Code
43191504
eClass
N03AA02
HSN No
29335300 / 30049081
Molecular Weight
254.22 g/mol
XLogP3
1.5
Complexity
339
Physical Form
Crystalline powder
Color
White to off-white
Melting Point
174–178 °C
Boiling Poin
Decomposes before boiling
pKa
~7.3
Signal Word
Warning
GHS Classification
H302: Harmful if swallowed H361: Suspected of damaging fertility or the unborn child

Antiepileptic Therapy

Used in the treatment and management of all types of seizures, especially generalized tonic-clonic and partial seizures.

Sedative & Hypnotic Use

Previously employed as a sedative-hypnotic for short-term insomnia and anxiety-related conditions.

Veterinary Use

Also used as an antiepileptic and anesthetic adjunct in veterinary medicine.

Variations

– Base form is utilized in tablets and capsules. – Sodium salt is used in injectable and rapid-onset oral solutions.

Medical Significance

Used as a first-line antiepileptic agent in both human and veterinary medicine. Long-acting action, affordability make it especially valuable in resource-limited medical settings.

Additional Features

-High Potency: Effective at low therapeutic doses. -Long Half-Life: Suitable for once-daily administration in epilepsy management. -Cost-Effective: One of the oldest and most affordable anticonvulsants globally.

Storage Temperature

15–30 °C

Container Type

Packed in HDPE bottles or aluminum drums with moisture-barrier liners

Stability

24 months from the date of manufacture in original sealed packaging Handling Precaution: Avoid exposure to excessive heat and humidity

  1. Acid, Phenylethylbarbituric
  2. Gardenal
  3. Hysteps
  4. Luminal
  5. Monosodium Salt Phenobarbital

Phenobarbital FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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