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N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine

N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine

CAS Number: 1421372-94-2

Molecular Formula: C20H16FN5O3

About N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine

Osimertinib Intermediate 1 (CAS 1421372-94-2) is a critical precursor in the oncology sector, specialized for the synthesis of third-generation EGFR inhibitors used in non-small cell lung cancer treatments, with current market trends showing increased demand for high purity fine chemicals from US-based CDMOs to ensure ...

N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine Specifications

CAS Number

1421372-94-2

Molecular Formula

C20H16FN5O3

Molecular Weight

393.37 g/mol

IUPAC Name

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine

Canonical SMILES

CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=CC(=C(C=C4OC)F)[N+](=O)[O-]

InChI Key

SZTYQQYYIMVETL-UHFFFAOYSA-N

PubChem CID

71239058

CAS Number

1421372-94-2

Molecular Formula

C20H16FN5O3

Molecular Weight

393.37 g/mol

IUPAC Name

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine

Canonical SMILES

CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=CC(=C(C=C4OC)F)[N+](=O)[O-]

InChI Key

SZTYQQYYIMVETL-UHFFFAOYSA-N

PubChem CID

71239058

Molecular Weight

393.37 g/mol

Physical appearance

Yellow solid

Pharmaceutical Intermediate

A key building block and critical intermediate primarily used in the synthesis of Osimertinib (AZD9291), a third-generation EGFR tyrosine kinase inhibitor for the treatment of non-small cell lung cancer

Chemical Reagent

An organic synthesis reagent utilized in the development of dihydropyrroloquinoline derivatives and other small molecules with potential anti-cancer activity

Scientific Research Tool

A specialized molecule used in drug discovery and academic research to study biochemical processes and investigate the inhibition of mutant EGFR kinases like L858R/T790M.

N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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