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N-((1E)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene)methanamine, commonly known as a Schiff base derivative, is an intermediate in the synthesis of the antidepressant sertraline hydrochloride. This compound plays a crucial role in the manufacturing process of sertraline, which is widely prescribed for depression and anxiety disorders.
N-((1E)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene)methanamine, commonly known as a Schiff base derivative, is an intermediate in the synthesis of the antidepressant sertraline hydrochloride. This compound plays a crucial role in the manufacturing process of sertraline, which is widely prescribed for depression and anxiety disorders.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
Eye: Wash with plenty of water Skin: Wash with plenty of water Ingestion: Medical assistance for gastric lavage. Inhalation: Remove to fresh air, artificial respiration or oxygen if necessary. Notes to Physician Sertraline Tetralone Methanamine can be washed with plenty of water in case of any exposure
Respiratory: Protection Self-contained breathing apparatus Eye Protection: Wear safety goggles Other Protective Equipment: Protective clothing Skin: Full sleeves apron Clothing: Cotton
Serves as a key intermediate in the production of sertraline hydrochloride, an antidepressant medication.
Utilized in medicinal chemistry studies focused on developing and optimizing antidepressant compounds.
Wear surgical gloves
~Storage
Direct contract to skin
Available in various sizes, including 25g, 100g, and 500g, suitable for research and industrial applications.
This Schiff base derivative serves as a crucial intermediate in the synthesis of sertraline hydrochloride, a widely used antidepressant. Its specific chemical structure enables the final product to interact effectively with serotonin receptors.
The Schiff base configuration ensures that sertraline exhibits the appropriate selective serotonin reuptake inhibition (SSRI) activity, making it effective in treating depression and anxiety.
Yes, this Schiff base intermediate is produced on a large scale by chemical manufacturers and is essential for producing sertraline at an industrial scale.
Apart from sertraline, this intermediate can be used to create other Schiff base derivatives that are useful in developing new antidepressants or other bioactive molecules.
As a pharmaceutical intermediate, it should be handled with care and appropriate protective equipment should be used. Always follow the safety guidelines provided by the manufacturer.
N-((1E)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene)methanamine is primarily used in the production of sertraline, which is prescribed for depression and anxiety disorders.
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