Lansoprazoleis (CAS 103577-45-3), a potent, substituted Benzimidazole Proton Pump Inhibitor (PPI) API classified as an antiulcer and antisecretory agent. As a prodrug, Lansoprazole's therapeutic potency is unleashed within the highly acidic environment (pH < 4) of the gastric parietal cell canaliculi. There, Lansoprazole undergoes an acid-catalysed transformation into its active form, a tetracyclic sulfenamide intermediate. This active metabolite achieves its profound acid suppression by forming stable, covalent disulfide bonds with specific cysteine residues on the gastric H⁺/K⁺-ATPase enzyme (as proton pump). This binding causes the irreversible inactivation of the pump, effectively blocking the final step of acid secretion into the stomach lumen, ensuring a prolonged therapeutic effect (up to 24-48 hours) necessary for the effective healing of GERD and ulcers, which is why the API must be meticulously formulated with enteric coating and alkaline stabilisers to survive gastric transit. Also called 'Prevacid' or ‘Lansoprazolum’ by Lansoprazole manufacturers. We are the leading Lansoprazole supplier worldwide with usp grade specifically ensuring comprehensive regulatory support & CoA traceability with global supply capability with reliable lead time.
Lansoprazoleis (CAS 103577-45-3), a potent, substituted Benzimidazole Proton Pump Inhibitor (PPI) API classified as an antiulcer and antisecretory agent. As a prodrug, Lansoprazole's therapeutic potency is unleashed within the highly acidic environment (pH < 4) of the gastric parietal cell canaliculi. There, Lansoprazole undergoes an acid-catalysed transformation into its active form, a tetracyclic sulfenamide intermediate. This active metabolite achieves its profound acid suppression by forming stable, covalent disulfide bonds with specific cysteine residues on the gastric H⁺/K⁺-ATPase enzyme (as proton pump). This binding causes the irreversible inactivation of the pump, effectively blocking the final step of acid secretion into the stomach lumen, ensuring a prolonged therapeutic effect (up to 24-48 hours) necessary for the effective healing of GERD and ulcers, which is why the API must be meticulously formulated with enteric coating and alkaline stabilisers to survive gastric transit. Also called 'Prevacid' or ‘Lansoprazolum’ by Lansoprazole manufacturers. We are the leading Lansoprazole supplier worldwide with usp grade specifically ensuring comprehensive regulatory support & CoA traceability with global supply capability with reliable lead time.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
(Gastric Acid Suppression) Short-term treatment and maintenance of Gastroesophageal Reflux Disease (GERD) and Erosive Esophagitis (EE)
(Ulcer Healing) Treatment of active Duodenal Ulcers, Gastric Ulcers, and those associated with NSAID use
(H. pylori Eradication) Key component in Triple Therapy regimens (Lansoprazole + two antibiotics) to treat H. pylori infections
(Acid Control Conditions) Management of pathological hypersecretory conditions, notably Zollinger-Ellison Syndrome (ZES)
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