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HBTU (CAS 94790-37-1) is a premier coupling reagent within the US API intermediates market, essential for high-efficiency peptide synthesis and the production of complex macrocyclic pharmaceuticals where Pharma/API purity 99% is required to ensure optimal yield and minimal epimerization. N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate acts as a critical high purity fine chemical for domestic CDMOs who are increasingly seeking custom synthesis services to streamline their solid-phase peptide synthesis (SPPS) workflows while navigating evolving FDA regulatory landscapes. 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is further utilized in general industry applications at a purity of 98% for the development of specialty polymers and biochemical probes, reflecting a growing demand for a reliable bulk chemical supplier capable of providing robust technical data packages to support North American manufacturing resilience. We are an established HBTU intermediates supplier with >= 99% purity in the united states, ensuring minimal carry-over of impurities in the final API, and a broad range of various pharmaceutical intermediates for API manufacturers and finished formulators, providing comprehensive analytical (HPLC/NMR/MS) and supporting HBTU COA/TDS/SDS region-specific regulatory support. reliable lead times, worldwide supply chain capabilities
HBTU (CAS 94790-37-1) is a premier coupling reagent within the US API intermediates market, essential for high-efficiency peptide synthesis and the production of complex macrocyclic pharmaceuticals where Pharma/API purity 99% is required to ensure optimal yield and minimal epimerization. N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate acts as a critical high purity fine chemical for domestic CDMOs who are increasingly seeking custom synthesis services to streamline their solid-phase peptide synthesis (SPPS) workflows while navigating evolving FDA regulatory landscapes. 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is further utilized in gen...
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Intermediates & Precursors
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Chemical Properties & Specifications
P210, P240, P241, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, and P501
Skin Irrit. 2 (100%)
Eye Irrit. 2A (100%)
A widely utilized uronium salt reagent primarily used for the activation of free carboxylic acids to facilitate efficient amide bond formation in both solid-phase and solution-phase peptide synthesis
A versatile coupling agent employed in the construction of complex molecules, including natural products, macrocycles, and pharmaceutical intermediates through the formation of amide and ester linkages
A functional reagent used to facilitate the conjugation of carboxylic acid-containing molecules to amine-bearing biomolecules such as proteins, antibodies, and oligonucleotides
A critical component in the one-pot synthesis of acyl azides, ureas, and carbamates, as well as in the construction of sulfoguanidine analogs and metal-organic complexes.
HBTU, also known as 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, is a premier coupling reagent primarily used in solid-phase and solution-phase peptide synthesis to activate carboxylic acids for amide bond formation
This reagent is widely used in the pharmaceutical, biotechnology, and agrochemical industries, as well as in academic research for drug development and biochemical studies
It is soluble in organic solvents such as DMF and DMSO and is compatible with standard Fmoc-based solid-phase peptide synthesis protocols
Standard specifications include CAS number 94790-37-1, high purity (typically ≥98% or ≥99% by HPLC), and availability of documentation such as COA, TDS, impurity reports, and regulatory compliance documents
Scimplify has capabilities for global distribution and custom synthesis through an integrated network of manufacturers and logistics partners with reliable lead time
The product is export ready with a standard MOQ starting from 100 kgs, with lead times for international customers depending on the shipping destination and specific grade.
Category : Pharmaceutical Actives & Precursors
Sub-Category : Intermediates & Precursors
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