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DTT (DL-1,4-Dithiothreitol)

DTT (DL-1,4-Dithiothreitol)

CAS Number: 3483-12-3

Molecular Formula: C4H10O2S2

About DTT (DL-1,4-Dithiothreitol)

"DTT (DL-1,4-Dithiothreitol) is a small-molecule reducing agent widely used in biochemistry and molecular biology. It functions by reducing disulfide bonds in proteins and peptides, helping maintain enzyme activity and protein stability by preventing oxidation. It is an enantiomer of a L-1,4-dithiothreitol. A reagent c...

DTT (DL-1,4-Dithiothreitol) Specifications

CAS Number
3483-12-3
Molecular Formula
C4H10O2S2
Molecular Weight
154.25 g/mol
IUPAC Name
(2R,3R)-1,4-bis(sulfanyl)butane-2,3-diol
Canonical SMILES
C(C(C(CS)O)O)S
InChI Key
VHJLVAABSRFDPM-IMJSIDKUSA-N
InChI
S/C4H10O2S2/c5-3(7)1-2-4(6)8/h3-6,7-8H,1-2H2/t3-,4+
PubChem CID
439196
EINECS Number
222-468-7
MDL Number
MFCD00004855
UNSPSC Code
12352100
eClass
39021701
NACRES
NA.26
Molecular Weight
154.25 g/mol
Appearance
White crystalline powder
Odor
Sulfur-like odor
Solubility
Highly soluble in water, ethanol, and methanol
Stability
highly sensitive to oxidation
Melting Point
42-44°C
Boiling Point
125-130°C (decomposes)
Density
1.26 g/cm³
GHS Classification
Acute Toxicity (Oral): Category 4 Skin Irritation: Category 2 Eye Irritation: Category 2A Hazardous to the Aquatic Environment (Chronic): Category 3
Hazard Statements
H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H412: Harmful to aquatic life with long-lasting effects.
Precautionary Statements
P280: Wear protective gloves and eye protection. P301+P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. P302+P352: IF ON SKIN: Wash with plenty of water. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. P273: Avoid release to the environment.

Biochemistry and Molecular Biology

Used as a reducing agent to maintain protein stability.

Protein Folding Studies

Prevents incorrect disulfide bond formation in proteins, aiding in protein folding studies.

Enzyme Stability Enhancement

Protects enzymatic activity by maintaining thiol groups in their reduced state.

RNA and DNA Research

Used in electrophoresis to prevent nucleic acid oxidation.

Temperature

Store at room temperature (typically 15–30°C or 59–86°F).

Environment

Keep in a dry, inert atmosphere. Avoid exposure to air, moisture, and oxidizing agents.

Protection

Store in original, tightly sealed containers under nitrogen or argon gas to prevent oxidation.

Packaging Options

Available in 1 g, 5 g, 10 g, and bulk quantities. Custom packaging available upon request.

DTT (DL-1,4-Dithiothreitol) FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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