Domperidone Maleate is a selective dopamine D2 receptor antagonist used in treating gastrointestinal motility disorders and nausea. Unlike centrally acting agents, it does not significantly cross the blood–brain barrier, making it preferred in patients sensitive to extrapyramidal side effects. It’s formulated as an API in solid oral dosage forms and suspensions. Stable Salt Form: Maleate version is preferred for improved solubility and oral bioavailability.
Domperidone Maleate is a selective dopamine D2 receptor antagonist used in treating gastrointestinal motility disorders and nausea. Unlike centrally acting agents, it does not significantly cross the blood–brain barrier, making it preferred in patients sensitive to extrapyramidal side effects. It’s formulated as an API in solid oral dosage forms and suspensions. Stable Salt Form: Maleate version is preferred for improved solubility and oral bioavailability.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
Used in the treatment of delayed gastric emptying, GERD, and functional dyspepsia.
Indicated for prevention and treatment of nausea and vomiting caused by gastrointestinal disorders or chemotherapy.
Sometimes used off-label to increase prolactin levels for postpartum lactation support.
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