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Domperidone maleate

Domperidone maleate

CAS Number: 83898-65-1

Molecular Formula: C22H24ClN5O2

Purity: 99.61%

Pharmacopoeias-IP/BP/Ph.EurTherapeutic category: Antagonists, AntimePeripheral Action : Low CNS penetrationCDSCO India ListedD2 Receptor Antagonis

About Domperidone maleate

Domperidone Maleate is a selective dopamine D2 receptor antagonist used in treating gastrointestinal motility disorders and nausea. Unlike centrally acting agents, it does not significantly cross the blood–brain barrier, making it preferred in patients sensitive to extrapyramidal side effects. It’s formulated as an API...

Synonyms

  • Apo Domperidone
  • Apo-Domperidone
  • Domidon
  • Domperidon
  • Domperidon AL
View all

Domperidone maleate Specifications

CAS Number
83898-65-1
Molecular Formula
C22H24ClN5O2
IUPAC Name
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Canonical SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
InChI Key
FGXWKSZFVQUSTL-UHFFFAOYSA-N
InChI
1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
PubChem CID
3151
EINECS Number
260-968-7
MDL Number
MFCD00069256
eClass
34-14-01-01
NACRES
P104D001
HSN No
29420090 (India)
Solubility
Insoluble in water, soluble in Dimethylformamide, slightly soluble in ethanol and in methanol
Appearance
A white or almost white powder
HPLC purity
99.61%
Assay
99.80%
GHS Classification
Not classified as hazardous
Toxicology
QT prolongation risk in high doses – avoid in cardiac patients without ECG monitoring
Handling
Use PPE, avoid inhalation or contact with skin/eyes

Prokinetic Agent

Used in the treatment of delayed gastric emptying, GERD, and functional dyspepsia.

Antiemetic

Indicated for prevention and treatment of nausea and vomiting caused by gastrointestinal disorders or chemotherapy.

Lactation Inducer

Sometimes used off-label to increase prolactin levels for postpartum lactation support.

Storage Condition

Store in tightly sealed container, away from light and moisture

Packaging

1 kg / 5 kg / 25 kg HDPE drums with double liner

Shelf Life

3–5 years under controlled room temperature

COA
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MSDS
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  1. Apo Domperidone
  2. Apo-Domperidone
  3. Domidon
  4. Domperidon
  5. Domperidon AL

Domperidone maleate FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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