Dolutegravir Sodium

CAS Number: 1051375-19-9

Molecular Formula: C20H18F2N3NaO5

About Dolutegravir Sodium

Dolutegravir sodium (CAS 1051375-10-0), a premier HIV-1 integrase strand transfer inhibitor (INSTI), serves as a cornerstone in antiretroviral therapy regimens, with the US market experiencing a surge in demand for high purity fine chemicals to support both first-line treatment and pre-exposure prophylaxis (PrEP) initi...

Dolutegravir Sodium Specifications

CAS Number

1051375-19-9

Molecular Formula

C20H18F2N3NaO5

Molecular Weight

441.36 g/mol

IUPAC Name

sodium (3S,7R)-13-[(2,4-difluorophenyl)methylcarbamoyl]-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-olate

Canonical SMILES

C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-]

InChI Key

UGWJRRXTMKRYNK-VSLILLSYSA-M

PubChem CID

46216142

CAS Number

1051375-19-9

Molecular Formula

C20H18F2N3NaO5

Molecular Weight

441.36 g/mol

IUPAC Name

sodium (3S,7R)-13-[(2,4-difluorophenyl)methylcarbamoyl]-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-olate

Canonical SMILES

C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-]

InChI Key

UGWJRRXTMKRYNK-VSLILLSYSA-M

PubChem CID

46216142

Molecular Weight

441.36 g/mol

Physical appearance

White to Pale Yellow Solid

Antiretroviral Agent

A potent HIV integrase strand transfer inhibitor (INSTI) used in combination with other antiretroviral medicines for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adult and pediatric patients

HIV Integrase Inhibitor

A targeted therapeutic agent that blocks the strand transfer step of retroviral DNA integration, effectively halting the viral replication cycle

Prophylactic Agent

An antiviral medication employed as part of post-exposure prophylaxis (PEP) regimens to prevent HIV infection following potential exposure

Pharmaceutical Reference Standard

A high-purity compound used in analytical chemistry and quality control laboratories for the identification and quantification of active pharmaceutical ingredients in drug formulations.