Clobetasol propionate

CAS Number: 25122-46-7

Molecular Formula: C25H32ClFO5

Purity: Clobetasol propionate 98% purity

About Clobetasol propionate

Clobetasol propionate (CAS 25122-46-7) serves as a cornerstone super-high potency corticosteroid with a Pharma/API purity of 99%, primarily utilized in the high-growth US dermatology sector for the formulation of advanced topical therapies targeting severe plaque psoriasis and recalcitrant eczema. The 17-Propionate est...

Clobetasol propionate Specifications

CAS Number

25122-46-7

Molecular Formula

C25H32ClFO5

Molecular Weight

466.970

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Canonical SMILES

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl

InChI Key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

EINECS Number

246-634-3

MDL Number

MFCD00058499

HSN No

30049099

CAS Number

25122-46-7

Molecular Formula

C25H32ClFO5

Molecular Weight

466.970

IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Canonical SMILES

CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl

InChI Key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

EINECS Number

246-634-3

MDL Number

MFCD00058499

HSN No

30049099

Molecular Weight

466.970

PSA

80.670

LogP

4.10310

Density

1.28 g/cm3

Boiling Point

569ºC @ 760 mmHg

Melting Point

195.5-197ºC

Flash Point

297.9ºC

Refractive Index

1.56

Vapor Pressure

2.58E-15mmHg @ 25°C

Purity

Clobetasol propionate 98% purity

Safety Statement Codes

S26, S36

Risk Statement Codes

R36, 37, 38

Precautionary Statement Codes

P203, P260, P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Pharmaceutical Active Ingredient

A super-high potency topical corticosteroid used as the primary active component in various dermatological formulations including creams, ointments, gels, and shampoos to treat severe inflammatory skin conditions such as psoriasis, eczema, and lichen sclerosus

Anti-inflammatory Agent

A potent glucocorticoid receptor agonist that suppresses the production of pro-inflammatory cytokines and mediators to reduce swelling, redness, and itching

Immunosuppressive Agent

A therapeutic compound that inhibits T-lymphocyte activation and immune cell migration to manage autoimmune-related dermatoses

Antiproliferative Agent

A medicinal agent employed to normalize keratinocyte cell turnover and reduce skin thickening in plaque-type psoriasis.

Detail 1

Store in cool place

Detail 2

Keep container tightly closed in a dry and well-ventilated place

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

Explore Pharmaceutical Portfolio

CAS No : 5743-26-0

Calcium acetate monohydrate

Category : Pharmaceutical Actives & Precursors

Sub-Category : Active Pharmaceutical Ingredients (APIs)

Description : Calcium acetate monohydrate (CAS No: 5743-26-0) occupies a critical position in the global specialit...

View Product

CAS No : 14168-73-1

Magnesium Sulphate Monohydrate

Category : Pharmaceutical Actives & Precursors, Inorganic Chemicals

Sub-Category : Active Pharmaceutical Ingredients (APIs), Inorganic Salts

Description : We supply high-efficiency magnesium sulphate monohydrate (CAS No: 14168-73-1) archieved across inter...

View Product

CAS No : 122-04-3

P-Nitrobenzoyl Chloride

Category : Pharmaceutical Actives & Precursors

Sub-Category : Intermediates & Precursors

Description : P-Nitrobenzoyl Chloride (CAS 122-04-3) is a critical building block in the API intermediates market,...

View Product

CAS No : 35271-74-0

Category : Pharmaceutical Actives & Precursors

Sub-Category : Active Pharmaceutical Ingredients (APIs)

Description : 3-(4-Chlorophenyl)glutaric acid (CAS 35271-74-0) is a pivotal building block in the API intermediate...

View Product

Company

Resources

Partner with us

Clobetasol propionate

About Clobetasol propionate