Bempedoic Acid is an oral, once-daily ATP-citrate lyase inhibitor and prodrug activated by hepatic ACSVL1 enzyme. By interrupting early cholesterol biosynthesis, it lowers LDL-C and is indicated for patients intolerant to statins or requiring additional LDL-C reduction. Bempedoic Acid manufactured on the purpose of Cardiovascular Therapeutic Agent end usage. It is also called as ETC-1002, acido bempedoico, Nexletol by suppliers.
Bempedoic Acid is an oral, once-daily ATP-citrate lyase inhibitor and prodrug activated by hepatic ACSVL1 enzyme. By interrupting early cholesterol biosynthesis, it lowers LDL-C and is indicated for patients intolerant to statins or requiring additional LDL-C reduction. Bempedoic Acid manufactured on the purpose of Cardiovascular Therapeutic Agent end usage. It is also called as ETC-1002, acido bempedoico, Nexletol by suppliers.
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Pharmaceutical
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Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
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Chemical Properties & Specifications
Serves as a prodrug that inhibits ACL in hepatocytes, effectively reducing hepatic cholesterol and LDL-C levels.
Used in the formulation of Nexletol® and fixed-dose combinations (e.g., with ezetimibe).
R&D and commercial production of lipid-lowering pharmaceuticals, particularly for patients unable to tolerate statins.
Requires hepatic ACSVL1 enzyme-confers liver-specific activity, reducing muscle toxicity
Inhibits ACL and activates AMPK in vitro- may confer anti-inflammatory effects
Weak inhibition of OATPs and OATs; no CYP450 involvement minimizes interaction risk
Low solubility, high permeability critical for formulation strategies
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