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Bempedoic Acid

Bempedoic Acid

CAS Number: 738606-46-7

Molecular Formula: C19H36O5

ATP‑Citrate Lyase InhibitorLDL‑C Management Oral ProdrugLipid‑Lowering AgentInhibits ACL & activates AMPKBCS Class IIIndia DCGI: Approved local MAHEU EMA: Authorized primary hypercholesterolemia

About Bempedoic Acid

Bempedoic Acid (CAS No. 738606-46-7) is a novel lipid-lowering active pharmaceutical ingredient (API) widely used in the United States for the treatment of hypercholesterolemia and cardiovascular risk management. As a first-in-class ATP citrate lyase (ACL) inhibitor, it works upstream of statins to reduce cholesterol b...

Synonyms

  • 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
  • bempedoic acid
  • ESP-55016
  • ESP55016
  • ETC-1002
View all

Bempedoic Acid Specifications

CAS Number
738606-46-7
Molecular Formula
C19H36O5
IUPAC Name
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
Canonical SMILES
CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
InChI Key
HYHMLYSLQUKXKP-UHFFFAOYSA-N
InChI
1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
PubChem CID
10472693
Melting Point
~87-92°C
Appearance
White to off-white crystalline powder
Protein Binding
~99.3%
Half‑Life
~21 ± 11 hours
Excretion
~70% urine, ~30% feces
GHS Classification
Low systemic toxicity; non-carcinogenic; avoid ingestion. Not classified as hazardous under standard lab handling.
Handling
Use standard lab PPE.
ICH Classification
Non-carcinogenic, non-mutagenic (per ICH S2(R1))

Hypercholesterolemia Drug Formulations (FDA-Approved Use)

Used by US pharmaceutical companies to develop oral therapies for lowering LDL-C in patients with primary hyperlipidemia and heterozygous familial hypercholesterolemia (HeFH).

ASCVD Risk Reduction Therapies

Incorporated into treatment regimens targeting patients with atherosclerotic cardiovascular disease (ASCVD), supporting long-term cardiovascular risk management in the US population.

Statin-Intolerant Patient Solutions

A key API for developing therapies for patients experiencing statin-associated muscle symptoms (SAMS), a significant segment in the US healthcare market.

Fixed-Dose Combination Drugs

Extensively used in combination with other lipid-lowering agents (such as cholesterol absorption inhibitors) to enhance efficacy and patient compliance in the US prescription markets.

Preventive Cardiology & Managed Care Programs

Integrated into preventive healthcare strategies across US clinical settings to reduce cardiovascular events and improve population health outcomes.

Contract Development & Manufacturing (CDMO) Applications

Utilized by US-based CDMOs and pharmaceutical manufacturers for API sourcing, formulation development, clinical trials, and commercial-scale production.

Storage

Store at 2–8 °C in a tightly sealed container; protect from moisture.

  1. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
  2. bempedoic acid
  3. ESP-55016
  4. ESP55016
  5. ETC-1002

Bempedoic Acid FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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