Azacitidine

CAS Number: 320-67-2

Molecular Formula: C8H12N4O5

Purity: 98% purity

About Azacitidine

Azacitidine (CAS 320-67-2) serves as a critical hypomethylating agent for treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), with the US market seeing a significant shift toward oral formulations to enhance patient compliance and outpatient care. 5-Azacytidine is increasingly sought from a bulk ...

Azacitidine Specifications

CAS Number

320-67-2

Molecular Formula

C8H12N4O5

Molecular Weight

244.20 g/mol

IUPAC Name

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

Canonical SMILES

C1=NC(=NC(=O)N1[C@H]2[C@H](C([C@H](O2)CO)O)O)N

InChI Key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

PubChem CID

9444

CAS Number

320-67-2

Molecular Formula

C8H12N4O5

Molecular Weight

244.20 g/mol

IUPAC Name

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

Canonical SMILES

C1=NC(=NC(=O)N1[C@H]2[C@H](C([C@H](O2)CO)O)O)N

InChI Key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

PubChem CID

9444

Molecular Weight

244.20 g/mol

Purity

98% purity

Physical appearance

White to almost white powder to crystal

Antineoplastic Chemotherapy Agent

A pyrimidine nucleoside analogue of cytidine used as a front-line treatment for various subtypes of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) by inhibiting DNA methyltransferase to induce DNA hypomethylation and exert direct cytotoxicity

DNA Methyltransferase Inhibitor

A potent hypomethylating agent that covalently binds to DNA methyltransferases (DNMTs) to trigger their degradation, thereby reactivating silenced tumor suppressor genes and restoring normal cell regulatory mechanisms in hematopoietic cells

Pharmaceutical Intermediate

A critical building block and active pharmaceutical ingredient (API) utilized in the formulation of specialized oncology medications, including both parenteral and oral dosage forms for long-term hematologic disease management.