Amoxicillin Trihydrate

CAS Number: 61336-70-7

Molecular Formula: C16H25N3O8S

Pharmacopeia: USP, EP, BP, IPTherapeutic: Beta-Lactam AntibioticClass: (Aminopenicillin)

About Amoxicillin Trihydrate

Amoxicillin Trihydrate (CAS 61336-70-7) is a foundational Semi-Synthetic, Broad-Spectrum Aminopenicillin API within the beta-lactam class, valued for its enhanced stability and superior oral bioavailability in its trihydrate form. Therapeutic power is rooted in its bactericidal mechanism, which involves irreversibly bi...

Amoxicillin Trihydrate Specifications

CAS Number

61336-70-7

Molecular Formula

C16H25N3O8S

Molecular Weight

419.450

IUPAC Name

(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate

Canonical SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C.O.O.O

InChI Key

MQXQVCLAUDMCEF-CWLIKTDRSA-N

InChI

1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

HSN No

2941109200

CAS Number

61336-70-7

Molecular Formula

C16H25N3O8S

Molecular Weight

419.450

IUPAC Name

(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate

Canonical SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C.O.O.O

InChI Key

MQXQVCLAUDMCEF-CWLIKTDRSA-N

InChI

1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

HSN No

2941109200

Molecular Weight

419.450

PSA

185.950

Density

1.54g/cm3

Boiling Point

743.2ºC at 760 mmHg

Vapour Melting Point

>200ºC (dec.)

Flash Point

403.3ºC

Refractive Index

302°(C=0.1, H2O)

GHS Hazard Statements

H317 (78%): May cause an allergic skin reaction H334 (99.5%): May cause allergy or asthma symptoms or breathing difficulties if inhale H400 (19.2%): Very toxic to aquatic life H410 (19.2%): Very toxic to aquatic life with long-lasting effects

Precautionary Statement Codes

P233, P260, P261, P271, P272, P273, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P391, P403, and P501

Risk Statement Codes

R42/43

Hazard Class

Acute Tox. 4 (100%) Skin Sens. 1 (99.1%) Aquatic Chronic 2 (99.1%)

Infections

Treatment of infections of the ear, nose, throat (e.g., strep throat, tonsillitis), genitourinary tract, skin/skin structure, and lower respiratory tract (e.g., pneumonia, bronchitis) caused by susceptible beta-lactamase-negative microorganisms

H. pylori Eradication

Multi-drug regimens (often triple therapy with a proton pump inhibitor and a macrolide, like clarithromycin) to treat Helicobacter pylori infection and associated peptic ulcers

Prophylaxis

Prophylaxis against bacterial endocarditis in high-risk patients undergoing dental or surgical procedures

Combination Therapy

Frequently combined with a beta-lactamase inhibitor, such as clavulanic acid (e.g., Amoxicillin/Clavulanate), to extend its spectrum of activity against beta-lactamase-producing resistant bacteria.

Storage Temperature

Cool, dark place, preferably below 15°C or 2°C-8°C (refrigerated)

Condition to Avoid

Hygroscopicity is a major concern. Avoid excess heat and moisture

Atmosphere

Store under an Inert Atmosphere (e.g., nitrogen) is recommended for bulk API

Packaging

Sealed HDPE drums or containers lined with double polyethylene bags. Desiccants should be included in the outer packaging.

Amoxicillin Trihydrate FAQs

Minimum Order Quantity

25 kg (evaluation) · 1 MT (commercial)

Lead Time

3 – 5 weeks estimated

Delivery Terms

FOB*

Packaging

20 L pails, 200 L HDPE drums, 1000 L IBC

US Availability

US Facility Inventory

Documentation

US SDS · COA · TDS · Specification sheet

US Regulatory & Quality Information

TSCA status*

US SDS / HazCom*

GHS classification*

ISO 9001:2015 site*

DOT shipping classification*

FDA status*

EPA status*

California Prop 65*

Reliable US supply chain

Regulatory compliance

On-time delivery

Technical expert support

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Amoxicillin Trihydrate

About Amoxicillin Trihydrate