Adapalene USP/BP

CAS Number: 106685-40-9

Molecular Formula: C28H28O3

Purity: Adapalene 98% purity

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About Adapalene USP/BP

Adapalene (CAS 106685-40-9) serves as a cornerstone in the United States API intermediates market, where its role as a third-generation retinoid drives significant demand for high purity fine chemicals utilized in the synthesis of advanced dermatological formulations for acne and photoaging. Differin, the most recogniz...

Adapalene USP/BP Specifications

CAS Number

106685-40-9

Molecular Formula

C28H28O3

Molecular Weight

412.52 g/mol

IUPAC Name

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

Canonical SMILES

COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

InChI Key

LZCDAPDGXCYOEH-UHFFFAOYSA-N

HSN No

29163990

CAS Number

106685-40-9

Molecular Formula

C28H28O3

Molecular Weight

412.52 g/mol

IUPAC Name

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

Canonical SMILES

COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

InChI Key

LZCDAPDGXCYOEH-UHFFFAOYSA-N

HSN No

29163990

Molecular Weight

412.52 g/mol

Purity

Adapalene 98% purity

Physical appearance

White to light yellow powder to crystal

Melting Point

319-322 °C

Boiling Point

606.3±55.0 °C (Predicted)

Freezing point

319°C

logP

6.917

Precautionary Statement Codes

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

Skin Irrit. 2 (72.7%) Eye Irrit. 2 (72.7%)

Active Pharmaceutical Ingredient

A topical retinoid used primarily in the formulation of gels, creams, and lotions for the treatment of acne vulgaris by modulating cellular keratinization and inflammatory processes

Retinoic Acid Receptor (RAR) Agonist

A selective agonist for RARβ and RARγ receptors employed in biochemical research to study gene transcription, cell differentiation, and the inhibition of hepatitis B virus transcription

Cell Culture Supplement

A component used in the culturing of peripheral blood mononuclear cells (PBMC) and mixed lymphocyte reactions (MLR) to investigate effects on isolated macrophages

Pharmaceutical Secondary Standard

A certified reference material utilized in analytical laboratory testing and quality control assays for peak identification and potency verification according to USP/EP monographs.